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Expression of BAFF and BAFF receptors in primary Sjögren’s syndrome patients with ectopic germinal center-like structures
B cell-activating factor (BAFF) is an essential cytokine in primary Sjögren’s syndrome (pSS) physiopathology. It has been reported that pSS patients develop germinal center-like (GC-like) structures in their minor salivary glands (MSGs). BAFF, BAFF-R, TACI, and BCMA expression was analyzed in MSGs f...
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| Published in: | Clinical and experimental medicine 2020-11, Vol.20 (4), p.615-626 |
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| creator | Carrillo-Ballesteros, F. J. Palafox-Sánchez, C. A. Franco-Topete, R. A. Muñoz-Valle, J. F. Orozco-Barocio, G. Martínez-Bonilla, G. E. Gómez-López, C. E. Marín-Rosales, M. López-Villalobos, E. F. Luquin, S. Castañeda-Chávez, A. Oregon-Romero, Edith |
| description | B cell-activating factor (BAFF) is an essential cytokine in primary Sjögren’s syndrome (pSS) physiopathology. It has been reported that pSS patients develop germinal center-like (GC-like) structures in their minor salivary glands (MSGs). BAFF, BAFF-R, TACI, and BCMA expression was analyzed in MSGs from 29 subjects (nonspecific chronic sialadenitis and focal lymphocytic sialadenitis with the presence [pSS-GC(+)] or absence [pSS-GC(−)] of GC-like structures). Twenty-four percent of patients showed ectopic GC-like structures and a high focus score [
p
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| doi_str_mv | 10.1007/s10238-020-00637-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2410705927</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2410705927</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-bffa793c817a02a8e632cec3ec733c157755f3a41fc61fd97801cdf2e30bfe1e3</originalsourceid><addsrcrecordid>eNp9kUFuFDEQRVuISISEC7CyxIZNQ9mOx-5liDIQKRILwtpyPOXgocduXG5BJBZcg4twAW6Sk-DQIyFlwapKqverVP933XMOrziAfk0chDQ9COgBVlL38Kg75Grg_aCEebzvjRngSfeUaAvAlZFw2H0__zYVJIo5sRzYm9P1mrm0WZqCHqeaC7GY2FTizpVb9mH7-9dNwXT34ycxuk2bknfIJlcjpkrsa6yfGPqap-jZDZZdTG5kvs2w9GP8jIxqmX2d29Xj7iC4kfDZvh51H9fnV2fv-sv3by_OTi97L5Wo_XUITg_SG64dCGdwJYVHL9FrKT1XWisVpDvhwa942AzaAPebIFDCdUCO8qh7ueydSv4yI1W7i-RxHF3CPJMVJxw0qEHohr54gG7zXNoL95TizVpteKPEQvmSiQoGu3fHcrD3gdglENsCsX8DsdBEchFRg1Oz5t_q_6j-AKLWkTA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2451637781</pqid></control><display><type>article</type><title>Expression of BAFF and BAFF receptors in primary Sjögren’s syndrome patients with ectopic germinal center-like structures</title><source>Springer Link</source><creator>Carrillo-Ballesteros, F. J. ; Palafox-Sánchez, C. A. ; Franco-Topete, R. A. ; Muñoz-Valle, J. F. ; Orozco-Barocio, G. ; Martínez-Bonilla, G. E. ; Gómez-López, C. E. ; Marín-Rosales, M. ; López-Villalobos, E. F. ; Luquin, S. ; Castañeda-Chávez, A. ; Oregon-Romero, Edith</creator><creatorcontrib>Carrillo-Ballesteros, F. J. ; Palafox-Sánchez, C. A. ; Franco-Topete, R. A. ; Muñoz-Valle, J. F. ; Orozco-Barocio, G. ; Martínez-Bonilla, G. E. ; Gómez-López, C. E. ; Marín-Rosales, M. ; López-Villalobos, E. F. ; Luquin, S. ; Castañeda-Chávez, A. ; Oregon-Romero, Edith</creatorcontrib><description>B cell-activating factor (BAFF) is an essential cytokine in primary Sjögren’s syndrome (pSS) physiopathology. It has been reported that pSS patients develop germinal center-like (GC-like) structures in their minor salivary glands (MSGs). BAFF, BAFF-R, TACI, and BCMA expression was analyzed in MSGs from 29 subjects (nonspecific chronic sialadenitis and focal lymphocytic sialadenitis with the presence [pSS-GC(+)] or absence [pSS-GC(−)] of GC-like structures). Twenty-four percent of patients showed ectopic GC-like structures and a high focus score [
p
< 0.001
vs
pSS-GC(−)]. BAFF serum levels (sBAFF) were high in pSS patients (
p
= 0.025
vs
healthy subjects). However, the pSS-GC(−) group showed higher sBAFF levels than pSS-GC(+) patients. BAFF and BAFF-R glandular expression levels were higher in pSS-GC(+) patients, without significant differences compared to pSS-GC(−) patients. Soluble levels of BAFF correlated with anti-La/SSB antibodies and disease duration. Our results showed that BAFF could contribute to focal lymphocytic infiltration. The role of BAFF-binding receptors in MSGs is proposed as a mechanism for the possible establishment of ectopic GC-like structures and disease progression in some patients. In conclusion, this study supports previous evidence that considers the active BAFF system role in the pathogenesis of pSS and the need for strong biomarkers in this disease.</description><identifier>ISSN: 1591-8890</identifier><identifier>EISSN: 1591-9528</identifier><identifier>DOI: 10.1007/s10238-020-00637-0</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>BLyS protein ; Germinal centers ; Hematology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Salivary gland ; Serum levels ; Sjogren's syndrome</subject><ispartof>Clinical and experimental medicine, 2020-11, Vol.20 (4), p.615-626</ispartof><rights>Springer Nature Switzerland AG 2020</rights><rights>Springer Nature Switzerland AG 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-bffa793c817a02a8e632cec3ec733c157755f3a41fc61fd97801cdf2e30bfe1e3</citedby><cites>FETCH-LOGICAL-c352t-bffa793c817a02a8e632cec3ec733c157755f3a41fc61fd97801cdf2e30bfe1e3</cites><orcidid>0000-0001-6010-0837</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Carrillo-Ballesteros, F. J.</creatorcontrib><creatorcontrib>Palafox-Sánchez, C. A.</creatorcontrib><creatorcontrib>Franco-Topete, R. A.</creatorcontrib><creatorcontrib>Muñoz-Valle, J. F.</creatorcontrib><creatorcontrib>Orozco-Barocio, G.</creatorcontrib><creatorcontrib>Martínez-Bonilla, G. E.</creatorcontrib><creatorcontrib>Gómez-López, C. E.</creatorcontrib><creatorcontrib>Marín-Rosales, M.</creatorcontrib><creatorcontrib>López-Villalobos, E. F.</creatorcontrib><creatorcontrib>Luquin, S.</creatorcontrib><creatorcontrib>Castañeda-Chávez, A.</creatorcontrib><creatorcontrib>Oregon-Romero, Edith</creatorcontrib><title>Expression of BAFF and BAFF receptors in primary Sjögren’s syndrome patients with ectopic germinal center-like structures</title><title>Clinical and experimental medicine</title><addtitle>Clin Exp Med</addtitle><description>B cell-activating factor (BAFF) is an essential cytokine in primary Sjögren’s syndrome (pSS) physiopathology. It has been reported that pSS patients develop germinal center-like (GC-like) structures in their minor salivary glands (MSGs). BAFF, BAFF-R, TACI, and BCMA expression was analyzed in MSGs from 29 subjects (nonspecific chronic sialadenitis and focal lymphocytic sialadenitis with the presence [pSS-GC(+)] or absence [pSS-GC(−)] of GC-like structures). Twenty-four percent of patients showed ectopic GC-like structures and a high focus score [
p
< 0.001
vs
pSS-GC(−)]. BAFF serum levels (sBAFF) were high in pSS patients (
p
= 0.025
vs
healthy subjects). However, the pSS-GC(−) group showed higher sBAFF levels than pSS-GC(+) patients. BAFF and BAFF-R glandular expression levels were higher in pSS-GC(+) patients, without significant differences compared to pSS-GC(−) patients. Soluble levels of BAFF correlated with anti-La/SSB antibodies and disease duration. Our results showed that BAFF could contribute to focal lymphocytic infiltration. The role of BAFF-binding receptors in MSGs is proposed as a mechanism for the possible establishment of ectopic GC-like structures and disease progression in some patients. In conclusion, this study supports previous evidence that considers the active BAFF system role in the pathogenesis of pSS and the need for strong biomarkers in this disease.</description><subject>BLyS protein</subject><subject>Germinal centers</subject><subject>Hematology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Salivary gland</subject><subject>Serum levels</subject><subject>Sjogren's syndrome</subject><issn>1591-8890</issn><issn>1591-9528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kUFuFDEQRVuISISEC7CyxIZNQ9mOx-5liDIQKRILwtpyPOXgocduXG5BJBZcg4twAW6Sk-DQIyFlwapKqverVP933XMOrziAfk0chDQ9COgBVlL38Kg75Grg_aCEebzvjRngSfeUaAvAlZFw2H0__zYVJIo5sRzYm9P1mrm0WZqCHqeaC7GY2FTizpVb9mH7-9dNwXT34ycxuk2bknfIJlcjpkrsa6yfGPqap-jZDZZdTG5kvs2w9GP8jIxqmX2d29Xj7iC4kfDZvh51H9fnV2fv-sv3by_OTi97L5Wo_XUITg_SG64dCGdwJYVHL9FrKT1XWisVpDvhwa942AzaAPebIFDCdUCO8qh7ueydSv4yI1W7i-RxHF3CPJMVJxw0qEHohr54gG7zXNoL95TizVpteKPEQvmSiQoGu3fHcrD3gdglENsCsX8DsdBEchFRg1Oz5t_q_6j-AKLWkTA</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Carrillo-Ballesteros, F. J.</creator><creator>Palafox-Sánchez, C. A.</creator><creator>Franco-Topete, R. A.</creator><creator>Muñoz-Valle, J. F.</creator><creator>Orozco-Barocio, G.</creator><creator>Martínez-Bonilla, G. E.</creator><creator>Gómez-López, C. E.</creator><creator>Marín-Rosales, M.</creator><creator>López-Villalobos, E. F.</creator><creator>Luquin, S.</creator><creator>Castañeda-Chávez, A.</creator><creator>Oregon-Romero, Edith</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6010-0837</orcidid></search><sort><creationdate>20201101</creationdate><title>Expression of BAFF and BAFF receptors in primary Sjögren’s syndrome patients with ectopic germinal center-like structures</title><author>Carrillo-Ballesteros, F. J. ; Palafox-Sánchez, C. A. ; Franco-Topete, R. A. ; Muñoz-Valle, J. F. ; Orozco-Barocio, G. ; Martínez-Bonilla, G. E. ; Gómez-López, C. E. ; Marín-Rosales, M. ; López-Villalobos, E. F. ; Luquin, S. ; Castañeda-Chávez, A. ; Oregon-Romero, Edith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-bffa793c817a02a8e632cec3ec733c157755f3a41fc61fd97801cdf2e30bfe1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>BLyS protein</topic><topic>Germinal centers</topic><topic>Hematology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Salivary gland</topic><topic>Serum levels</topic><topic>Sjogren's syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrillo-Ballesteros, F. J.</creatorcontrib><creatorcontrib>Palafox-Sánchez, C. A.</creatorcontrib><creatorcontrib>Franco-Topete, R. A.</creatorcontrib><creatorcontrib>Muñoz-Valle, J. F.</creatorcontrib><creatorcontrib>Orozco-Barocio, G.</creatorcontrib><creatorcontrib>Martínez-Bonilla, G. E.</creatorcontrib><creatorcontrib>Gómez-López, C. E.</creatorcontrib><creatorcontrib>Marín-Rosales, M.</creatorcontrib><creatorcontrib>López-Villalobos, E. F.</creatorcontrib><creatorcontrib>Luquin, S.</creatorcontrib><creatorcontrib>Castañeda-Chávez, A.</creatorcontrib><creatorcontrib>Oregon-Romero, Edith</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrillo-Ballesteros, F. J.</au><au>Palafox-Sánchez, C. A.</au><au>Franco-Topete, R. A.</au><au>Muñoz-Valle, J. F.</au><au>Orozco-Barocio, G.</au><au>Martínez-Bonilla, G. E.</au><au>Gómez-López, C. E.</au><au>Marín-Rosales, M.</au><au>López-Villalobos, E. F.</au><au>Luquin, S.</au><au>Castañeda-Chávez, A.</au><au>Oregon-Romero, Edith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of BAFF and BAFF receptors in primary Sjögren’s syndrome patients with ectopic germinal center-like structures</atitle><jtitle>Clinical and experimental medicine</jtitle><stitle>Clin Exp Med</stitle><date>2020-11-01</date><risdate>2020</risdate><volume>20</volume><issue>4</issue><spage>615</spage><epage>626</epage><pages>615-626</pages><issn>1591-8890</issn><eissn>1591-9528</eissn><abstract>B cell-activating factor (BAFF) is an essential cytokine in primary Sjögren’s syndrome (pSS) physiopathology. It has been reported that pSS patients develop germinal center-like (GC-like) structures in their minor salivary glands (MSGs). BAFF, BAFF-R, TACI, and BCMA expression was analyzed in MSGs from 29 subjects (nonspecific chronic sialadenitis and focal lymphocytic sialadenitis with the presence [pSS-GC(+)] or absence [pSS-GC(−)] of GC-like structures). Twenty-four percent of patients showed ectopic GC-like structures and a high focus score [
p
< 0.001
vs
pSS-GC(−)]. BAFF serum levels (sBAFF) were high in pSS patients (
p
= 0.025
vs
healthy subjects). However, the pSS-GC(−) group showed higher sBAFF levels than pSS-GC(+) patients. BAFF and BAFF-R glandular expression levels were higher in pSS-GC(+) patients, without significant differences compared to pSS-GC(−) patients. Soluble levels of BAFF correlated with anti-La/SSB antibodies and disease duration. Our results showed that BAFF could contribute to focal lymphocytic infiltration. The role of BAFF-binding receptors in MSGs is proposed as a mechanism for the possible establishment of ectopic GC-like structures and disease progression in some patients. In conclusion, this study supports previous evidence that considers the active BAFF system role in the pathogenesis of pSS and the need for strong biomarkers in this disease.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10238-020-00637-0</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6010-0837</orcidid></addata></record> |
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| subjects | BLyS protein Germinal centers Hematology Internal Medicine Medicine Medicine & Public Health Oncology Original Article Salivary gland Serum levels Sjogren's syndrome |
| title | Expression of BAFF and BAFF receptors in primary Sjögren’s syndrome patients with ectopic germinal center-like structures |
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