The impact of cardiovascular risk factors on global longitudinal strain over a decade in the general population: the copenhagen city heart study

Global longitudinal strain (GLS) declines throughout adult-life as the LV remodels and adapts. Information on the impact of cardiac risk factors such as male sex, obesity, smoking status, hypertension, hypercholesterolemia, and diabetes on GLS. over time has not yet been investigated. The present pr...

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Bibliographic Details
Published in:The International Journal of Cardiovascular Imaging 2020-10, Vol.36 (10), p.1907-1916
Main Authors: Skaarup, Kristoffer Grundtvig, Lassen, Mats Christian Højbjerg, Marott, Jacob Louis, Biering-Sørensen, Sofie R., Jørgensen, Peter Godsk, Appleyard, Merete, Berning, Jens, Høst, Nis, Jensen, Gorm, Schnohr, Peter, Søgaard, Peter, Gislason, Gunnar, Møgelvang, Rasmus, Biering-Sørensen, Tor
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adult
Age
Aged
Blood pressure
Body mass
Body mass index
Body size
Cardiac Imaging
Cardiology
Cardiovascular diseases
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Correlation analysis
Denmark - epidemiology
Diabetes mellitus
Echocardiography, Doppler
Female
Health risks
Humans
Hypercholesterolemia
Hypertension
Imaging
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Predictive Value of Tests
Prognosis
Prospective Studies
Radiology
Regression models
Risk analysis
Risk Assessment
Risk Factors
Sex
Time Factors
Ventricular Function, Left
Ventricular Remodeling
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Summary:Global longitudinal strain (GLS) declines throughout adult-life as the LV remodels and adapts. Information on the impact of cardiac risk factors such as male sex, obesity, smoking status, hypertension, hypercholesterolemia, and diabetes on GLS. over time has not yet been investigated. The present prospective longitudinal study included 689 participants of the 4th and 5th Copenhagen City Heart Study who had GLS measured at both timepoints. Mean age was 51 years and 45% were male. All participants underwent two echocardiographic examinations median 10.4 (IQR: 10.2, 10.9) years apart. Average decline in GLS during follow-up was -0.7%. High age, male sex, high body mass index, and mean arterial blood pressure (MAP) proved to be significantly associated with an accelerated decline in GLS. In a multivariable regression model including all the investigated cardiovascular risk factors, age (stand. β-coef. = −0.10, P = 0.005), male sex (stand. β-coef. = −0.16, P 
ISSN:1569-5794
1573-0743
1875-8312
DOI:10.1007/s10554-020-01906-5