Recent advances in modulators of circadian rhythms: an update and perspective

Circadian rhythm is a universal life phenomenon that plays an important role in maintaining the multiple physiological functions and regulating the adaptability to internal and external environments of flora and fauna. Circadian alignment in humans has the greatest effect on human health, and circad...

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Published in:Journal of enzyme inhibition and medicinal chemistry 2020-01, Vol.35 (1), p.1267-1286
Main Authors: Huang, Shenzhen, Jiao, Xinwei, Lu, Dingli, Pei, Xiaoting, Qi, Di, Li, Zhijie
Format: Article
Language:English
Subjects:
Adaptability
Cardiovascular diseases
Circadian rhythm
Circadian Rhythm - drug effects
Circadian Rhythm - physiology
circadian rhythm-related disease
Circadian rhythms
clock proteins
Disease
Humans
Immunological diseases
Metabolic syndrome
Neurological diseases
Neuromodulation
post-modification targets
Review
Sleep
Sleep disorders
small-molecule modulators
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creator Huang, Shenzhen
Jiao, Xinwei
Lu, Dingli
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description Circadian rhythm is a universal life phenomenon that plays an important role in maintaining the multiple physiological functions and regulating the adaptability to internal and external environments of flora and fauna. Circadian alignment in humans has the greatest effect on human health, and circadian misalignment is closely associated with increased risk for metabolic syndrome, cardiovascular diseases, neurological diseases, immune diseases, cancer, sleep disorders, and ophthalmic diseases. The recent description of clock proteins and related post-modification targets was involved in several diseases, and numerous lines of evidence are emerging that small molecule modulators of circadian rhythms can be used to rectify circadian disorder. Herein, we attempt to update the disclosures about the modulators targeting core clock proteins and related post-modification targets, as well as the relationship between circadian rhythm disorders and human health as well as the therapeutic role and prospect of these small molecule modulators in circadian rhythm related disease.
doi_str_mv 10.1080/14756366.2020.1772249
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source PubMed Central (Open Access); Taylor & Francis Open Access; Publicly Available Content Database
subjects Adaptability
Cardiovascular diseases
Circadian rhythm
Circadian Rhythm - drug effects
Circadian Rhythm - physiology
circadian rhythm-related disease
Circadian rhythms
clock proteins
Disease
Humans
Immunological diseases
Metabolic syndrome
Neurological diseases
Neuromodulation
post-modification targets
Review
Sleep
Sleep disorders
small-molecule modulators
title Recent advances in modulators of circadian rhythms: an update and perspective
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