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Pretreatment serum neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios: Two tumor-related systemic inflammatory markers in patients with thymic epithelial tumors

•Serum NLR and MLR are higher in TETs patients than in healthy volunteers.•High serum NLR and MLR are related to the TCs subtype, elevated M−K tumor stage, and metastasis of TETs.•High serum NLR and MLR are related to enhanced glycolytic activity of TETs.•Co-high SUVmax/NLR and co-high SUVmax/MLR in...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2020-09, Vol.133, p.155149-155149, Article 155149
Main Authors: Wang, Lihua, Ruan, Maomei, Yan, Hui, Lei, Bei, Sun, Xiaoyan, Chang, Cheng, Liu, Liu, Xie, Wenhui
Format: Article
Language:English
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Summary:•Serum NLR and MLR are higher in TETs patients than in healthy volunteers.•High serum NLR and MLR are related to the TCs subtype, elevated M−K tumor stage, and metastasis of TETs.•High serum NLR and MLR are related to enhanced glycolytic activity of TETs.•Co-high SUVmax/NLR and co-high SUVmax/MLR increase the risk of TETs metastasis. To understand underlying changes in pretreatment serum inflammatory markers associated with thymic epithelial tumors (TETs) development. A retrospective analysis of 113 TETs patients who underwent 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography combined computed tomography (PET/CT) one to two weeks before tumor resection or biopsy was performed. Pretreatment serum neutrophil, monocyte, platelet, and lymphocyte counts, and fibrinogen and C-reaction protein (CRP) concentrations were measured one day before surgery or biopsy. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were calculated by dividing corresponding cells counts by lymphocyte counts, respectively. The maximum standard uptake value (SUVmax) of 18F-FDG of primary TETs was applied to reflect tumor glycolytic activity. The student’s t-test, one-way ANOVA analysis, Chi-square test, receiver operating characteristic curve analysis, and Logistic regression analysis were used for statistical analysis. The serum NLR and MLR were significantly higher in TETs patients than in healthy volunteers (P both ≤ 0.001). High serum NLR and MLR were related to the thymic carcinomas (TCs) subtype, elevated Masaoka-Koga (M−K) tumor stage, and metastasis of TETs (P all 
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2020.155149