Influence of Human Paraoxonase-1 Polymorphism (Q192R) on Serum Levels of Clinical Biomarkers Indicatives of Cardiovascular Diseases Risk in Mexican Women

Human paraoxonase-1 (PON1) is a hydrolytic enzyme related in the onset, establishment, and progression of inflammatory illnesses, including cardiovascular diseases (CVD). Therefore, the primary goal of this investigation was to determinate the influence of the PON1 gene polymorphism (Q192R) on progn...

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Bibliographic Details
Published in:Biochemical genetics 2020-10, Vol.58 (5), p.801-820
Main Authors: Ochoa-Martínez, Ángeles C., Orta-García, Sandra T., Varela-Silva, José A., Pérez-Maldonado, Iván N.
Format: Article
Language:English
Subjects:
Adult
Arginine - analogs & derivatives
Arginine - blood
Aryldialkylphosphatase - genetics
Biochemistry
Biomarkers
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - genetics
Cross-Sectional Studies
Enzymes
Fatty Acid-Binding Proteins - blood
Female
Gene polymorphism
Genetic Predisposition to Disease
Heart Disease Risk Factors
Human Genetics
Humans
Medical Microbiology
Mexico
MicroRNAs - blood
Original Article
Paraoxonase
Polymorphism
Polymorphism, Genetic
Regression analysis
Regression models
Serum levels
Sex Factors
Zoology
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Summary:Human paraoxonase-1 (PON1) is a hydrolytic enzyme related in the onset, establishment, and progression of inflammatory illnesses, including cardiovascular diseases (CVD). Therefore, the primary goal of this investigation was to determinate the influence of the PON1 gene polymorphism (Q192R) on prognostic biomarkers of CVD in women ( n  = 350) from San Luis Potosi, Mexico. For everyone enrolled, anthropometric, clinical, and biochemical measurements were acquired. Q192R polymorphism of the PON1 gene was assessed by real-time PCR using TaqMan probes. Also, quantification and/or calculation of suggested predictive CVD biomarkers were completed. The association between PON1(Q192R) polymorphism with clinical predictive CVD biomarkers was assessed using univariate and multivariate logistic regression models. Genotype PON1 (Q192R) frequencies were: 18%, 47% and 35% for QQ, QR, and RR, respectively. Besides, the frequency of the variant R allele was 0.58. Furthermore, robust significant associations were found between PON1 (Q192R) polymorphism with serum ADMA [OR (95% CI); 3.50 (1.20–5.00), p  
ISSN:0006-2928
1573-4927
1573-4927
DOI:10.1007/s10528-020-09975-w