Cytoskeletal Repair: Microtubule Orthopaedics to the Rescue

While the dynamics of microtubule ends are well characterized, the mechanism that repairs breaks in the lattice interior is poorly understood. A new in vitro study finds that the microtubule-associated protein CLASP repairs lattice damage by regulating GTP-tubulin incorporation into the break site....

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Bibliographic Details
Published in:Current biology 2020-06, Vol.30 (11), p.R646-R649
Main Author: Slep, Kevin C.
Format: Article
Language:English
Subjects:
Microtubule-Associated Proteins
Microtubules
Orthopedics
Tubulin
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Summary:While the dynamics of microtubule ends are well characterized, the mechanism that repairs breaks in the lattice interior is poorly understood. A new in vitro study finds that the microtubule-associated protein CLASP repairs lattice damage by regulating GTP-tubulin incorporation into the break site. While the dynamics of microtubule ends are well characterized, the mechanism that repairs breaks in the lattice interior is poorly understood. A new in vitro study finds that the microtubule-associated protein CLASP repairs lattice damage by regulating GTP-tubulin incorporation into the break site.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2020.04.049