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Efficacy of homoeopathic treatment for diabetic distal symmetric polyneuropathy: A multicentric randomised double-blind placebo-controlled clinical trial

•The dearth of guidelines in conventional system of medicine for treating neuropathy and the positive outcomes of research trials conducted using homoeopathic medicines, the present double-blind randomised placebo-control clinical trial was carried out to evaluate the efficacy of homoeopathic treatm...

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Published in:Explore (New York, N.Y.) N.Y.), 2021-09, Vol.17 (5), p.417-423
Main Authors: Mehra, Pritha, Sharma, Bindu, Baig, Hafeezulla, Raveendar, Ch, Prasad, R.V.R., Rao, M.Prakash, Raju, Kolli, Arya, J.S., Manchanda, Raj K., Katarmal, Daisy, Kumar, Arvind
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Language:English
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Summary:•The dearth of guidelines in conventional system of medicine for treating neuropathy and the positive outcomes of research trials conducted using homoeopathic medicines, the present double-blind randomised placebo-control clinical trial was carried out to evaluate the efficacy of homoeopathic treatment using pre-identified medicines in the management of DDSP.•Neuropathy Total Symptom Score-6 – Healthcare Professional administered version, helped in evaluating the effect of treatment in this study and statistically significant improvement was found in the verum group.•Diabetic neuropathy examination score is a sensitive and validated hierarchical physical examination scoring system used in this study and the graph shows a positive trend in the verum group.•The results show that 25% of patients in the verum group showed improvement in the Nerve conduction study as compared to 13.8% patients in the placebo group. In course of diabetes, some 20–90% of individuals eventually develop diabetic neuropathy. Looking at the disease burden research studies in Homoeopathy were conducted and have shown positive results. These studies were not robust enough to prove the efficacy of individualized homoeopathy. To assess efficacy of individualized homoeopathic medicines in management of DDSP. A multi-centric double-blind, placebo controlled, randomised clinical trial was conducted by the Central Council for Research in Homoeopathy at six centres with a sample size of 84. Based on earlier observational studies and repertorial anamnesis of DDSP symptoms 15 homoeopathic medicines were shortlisted and validated scales were used for evaluating the outcomes post-intervention. Primary outcome measure was change in Neuropathy Total Symptom Score-6 (NTSS-6) from baseline to 12 months. Secondary outcomes included changes in peripheral nerve conduction study (NCS), World Health Organization Quality of Life BREF (WHOQOL-BREF) and Diabetic Neuropathy Examination (DNE) Score at 12 months. Data of 68 enrolled cases was considered for data analysis. Statistically significant difference (p
ISSN:1550-8307
1878-7541
DOI:10.1016/j.explore.2020.05.007