The critical role of Faecalibacterium prausnitzii in human health: An overview

• Published in: Microbial pathogenesis 2020-12, Vol.149, p.104344-104344, Article 104344
• Main Authors: Leylabadlo, Hamed Ebrahimzadeh, Ghotaslou, Reza, Feizabadi, Mohammad Mehdi, Farajnia, Safar, Moaddab, Seyed Yaghoub, Ganbarov, Khudaverdi, Khodadadi, Ehsaneh, Tanomand, Asghar, Sheykhsaran, Elham, Yousefi, Bahman, Kafil, Hossein Samadi
• Format: Article
• Language: English
• Subjects: Anti-inflammatory; Faecalibacterium prausnitzii; Gut microbiota; Microbiome
• ISSN: 0882-4010; 1096-1208
• DOI: 10.1016/j.micpath.2020.104344

Faecalibacterium prausnitzii (F. prausnitzii) is one of the most abundant bacterial species in the colon of healthy human adults and representing more than 5% of the total bacterial population. Recently, it has been known as a major actor in human intestinal health and a biosensor. Changes in this species population richness and quantity have been observed in many illnesses and several investigations have reported that abundance of F. prausnitzii is reduced in different intestinal disorders. In the current review, we aim to consider literature from various library databases and electronic searches (Science Direct, PubMed, and Google Scholar) which were randomly collected and serve as an overview of different features of F. prausnitzii including metabolites, anti-inflammatory action, and correlation of dysbiosis of this bacterium with various complications in human. •F. prausnitzii is one of the most abundant bacterial species in the colon of healthy human.•It has a major actor of human intestinal health and a biosensor.•Changes in this species population quantity have been observed in many illnesses.•It has role by metabolites, anti-inflammatory action, and correlation of dysbiosis.•This bacterium is a good biomarker in the certain gut conditions.