Pexophagy modes during penicillin biosynthesis in Penicillium rubens P2-32-T

Pexophagy is a peroxisome degradation process. The last two steps of penicillin biosynthesis in Penicillium rubens are carried out in peroxisomes. These organelles proliferate in large numbers during this process, so that after the penicillin secretion, their removal is essential as a regulatory mec...

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Bibliographic Details
Published in:Archives of microbiology 2020-10, Vol.202 (8), p.2337-2341
Main Authors: Campos, C., Lázaro-Rodríguez, T. G., Hernández-Pérez, E., Rincón-Heredia, R., Fernández, F. J.
Format: Article
Language:English
Subjects:
Antibiotics
Biochemistry
Biomedical and Life Sciences
Biosynthesis
Biotechnology
Cell Biology
Ecology
Fungi
Life Sciences
Microbial Ecology
Microbiology
Organelles
Penicillin
Penicillium
Peroxisomes
Pexophagy
Phagocytosis
Regulatory mechanisms (biology)
Short Communication
Transmission electron microscopy
Vacuoles
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Summary:Pexophagy is a peroxisome degradation process. The last two steps of penicillin biosynthesis in Penicillium rubens are carried out in peroxisomes. These organelles proliferate in large numbers during this process, so that after the penicillin secretion, their removal is essential as a regulatory mechanism. In this work, two pexophagy modes are described for the high-penicillin producing strain P. rubens P2-32-T, by transmission electron microscopy (TEM) on 24- and 48-h cultures (when maximum penicillin production is achieved). The obtained images show peroxisome phagocytosis by vacuoles in three different ways: macropexophagy, micropexophagy, and a new proposed model: unipexophagy.
ISSN:0302-8933
1432-072X
DOI:10.1007/s00203-020-01939-3