Trypanosomes of vectors and domestic dogs in Trypanosoma cruzi transmission areas from Brazilian southwestern amazon: New mammalian host for Trypanosoma janseni

•Dogs are probably not T. cruzi reservoirs in the studied area.•Dogs were infected by at least three trypanosoma species, including T. janseni.•Dogs can be considered reservoirs for T. janseni. Trypanosoma cruzi is a widespread protozoan in Latin America causing Chagas disease in humans and able to...

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Published in:Acta tropica 2020-10, Vol.210, p.105504-105504, Article 105504
Main Authors: Malavazi, Patrícia F.N.S., Daudt, Cíntia, Melchior, Leonardo A.K., Meneguetti, Dionatas U.O., Xavier, Samanta C.C., Jansen, Ana M., Souza, Soraia F., Roque, André L.R.
Format: Article
Language:English
Subjects:
Acre state
American trypanosomiasis
Animals
Brazil - epidemiology
Canine
Dogs
Humans
Pets - parasitology
Polymerase Chain Reaction
Triatomine
Trypanosoma cruzi - genetics
Trypanosoma cruzi - isolation & purification
Trypanosomatidae
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Summary:•Dogs are probably not T. cruzi reservoirs in the studied area.•Dogs were infected by at least three trypanosoma species, including T. janseni.•Dogs can be considered reservoirs for T. janseni. Trypanosoma cruzi is a widespread protozoan in Latin America causing Chagas disease in humans and able to infect several other mammal species. The objective of this study was to investigate the T. cruzi infection in triatomine fauna as well as in dogs from distinct areas of Acre, western Brazilian Amazonia, which recently reported acute cases of human CD as well as an area that have not notify this disease recently. Triatomines were collected and the intestinal contents were evaluated for the presence of trypanosomatids by optical microscopy and polymerase chain reaction (PCR) targeting the mini-exon gene. Blood smear, hemoculture, PCR and serology were performed in the studied mammals. Fecal content of four triatomines were positive (11.6%) in the fresh examination. Molecular analysis identified Trypanosoma cruzi TCI in two specimens. Blood samples from 90 dogs were obtained. Trypanosoma sp. was observed in six blood smears (6/83, 7.22%). Seropositivity for T. cruzi was 8/89 (8.98). One dog's hemoculture was obtained and characterized as T. rangeli. PCR reactions in blood clots resulted in one positive dog (1/75, 1.3%) infected by T. janseni, providing a new mammalian host for a recently described Trypanosoma species. The results demonstrate the low exposition and prevalence for T. cruzi suggesting that dogs are not important to T. cruzi transmission cycle in the studied áreas.
ISSN:0001-706X
1873-6254
DOI:10.1016/j.actatropica.2020.105504