Evaluation of rapid polymyxin Nordmann Poirel test for detection of polymyxin resistance in clinical isolates of Enterobacteriaceae

Polymyxins play a significant role against carbapenem-resistant Enterobacteriaceae (CRE). A total of 121 clinical samples yielded growth of CRE that were included in the study. Rapid Polymyxin NP test was performed on all the isolates as described by Nordmann P et al. and results were compared with...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2020-11, Vol.39 (11), p.2195-2198
Main Authors: Shoaib, Muhammad, Hussain, Ashfaq, Satti, Luqman, Hussain, Wajid, Zaman, Gohar, Hanif, Faisal
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Biomedical and Life Sciences
Biomedicine
Brief Report
Carbapenem-Resistant Enterobacteriaceae - drug effects
Carbapenem-Resistant Enterobacteriaceae - isolation & purification
Diagnostic Tests, Routine
Drug Resistance, Bacterial
Enterobacteriaceae Infections - drug therapy
Humans
Internal Medicine
Medical Microbiology
Microbial Sensitivity Tests
Pakistan
Polymyxins - pharmacology
Polymyxins - therapeutic use
Sensitivity and Specificity
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Summary:Polymyxins play a significant role against carbapenem-resistant Enterobacteriaceae (CRE). A total of 121 clinical samples yielded growth of CRE that were included in the study. Rapid Polymyxin NP test was performed on all the isolates as described by Nordmann P et al. and results were compared with broth microdilution method. Majority of the isolates were Klebsiella pneumoniae (70.2%) followed by Escherichia coli (17.4%). A total of 71 isolates were found resistant and 50 as susceptible by broth microdilution. Sensitivity and specificity of rapid polymyxin NP test were found to be 97.2% and 100%, respectively. Our study concluded that rapid polymyxin NP test is reliable and can be used as an alternative to broth microdilution in resource limited settings.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-020-03942-4