Resveratrol-loaded hollow kafirin nanoparticles via gallic acid crosslinking: An evaluation compared with their solid and non-crosslinked counterparts

[Display omitted] •Hollow resveratrol loaded kafirin nanoparticles (HRKNPs) were fabricated.•Gallic acid was used as the crosslinking agent in the kafirin nanoparticles.•HRKNPs had smaller size and higher loading efficiency than solid ones.•HRKNPs crosslinked with gallic acid (HRKNPs-G) were more re...

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Bibliographic Details
Published in:Food research international 2020-09, Vol.135, p.109308-109308, Article 109308
Main Authors: Pu, Chuanfen, Tang, Wenting, Liu, Mengyao, Zhu, Yinglian, Sun, Qingjie
Format: Article
Language:English
Subjects:
Biological Availability
Crosslinking
Gallic Acid
Hollow structure
Kafirin
Nanoparticles
Pharmaceutical Preparations
Resveratrol
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Summary:[Display omitted] •Hollow resveratrol loaded kafirin nanoparticles (HRKNPs) were fabricated.•Gallic acid was used as the crosslinking agent in the kafirin nanoparticles.•HRKNPs had smaller size and higher loading efficiency than solid ones.•HRKNPs crosslinked with gallic acid (HRKNPs-G) were more resistant to pancreatin.•HRKNPs-G showed a delayed release behavior. The possibility of combining the health benefits of kafirin and polyphenols and improving the bioavailability of resveratrol using hollow kafirin nanoparticles via gallic acid crosslinking was investigated. The size, morphology, charge state, loading efficiency, physicochemical stability, and redispersity after lyophilization of hollow resveratrol-loaded kafirin nanoparticles formed via gallic acid crosslinking were characterized and compared with their solid counterparts and those without crosslinking. The nanoparticles formed were anionic spheres with an average diameter of
ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2020.109308