18F-choline PET/4D CT in hyperparathyroidism: correlation between biochemical data and study parameters

• Published in: Revista Española de medicina nuclear e imagen molecular (English ed.) 2020-09, Vol.39 (5), p.273-278
• Main Authors: Boccalatte, L A, Gómez, N L, Musumeci, M, Galich, A M, Collaud, C, Figari, M F
• Format: Article
• Language: eng ; spa
• ISSN: 2253-8089
• DOI: 10.1016/j.remn.2020.03.017

BACKGROUNDHyperparathyroidism (HPT) is characterised by increased levels of parathyroid hormone (HPT), surgical excision being the only definitive curative option. After establishing the need for surgery, it is essential to identify the parathyroid glands in the preoperative period to use a minimally invasive approach. Negativity and / or discrepancy in first-line studies (ultrasound and Tc-99m MIBI parathyroid scintigraphy) require more accurate images to reduce the likelihood of bilateral cervical exploration or reintervention. OBJECTIVESa) To demonstrate the sensitivity of 18F-fluorocholine (18F-choline) positron emission tomography (PET)/4D computed tomography (4D CT) in HPT. b) To check whether there is a correlation between calcaemia and preoperative PTH versus size and early and late SUVmax (Standardized Uptake Value) of the gland, determined by 18F-choline PET/4D CT and c) to study the behaviour of parathyroid lesions with intravenous contrast (IV). MATERIAL AND METHODSA total of 28 patients were included between 2016 and 2019 in a single institution. Prospective observational cohort study. Correlations were analysed using Pearson's coefficient for variables with normal distribution and Spearman (rho) for those with non-normal distribution. Anatomopathological analysis was the benchmark standard to determine sensitivity was. A p