Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: a randomized double‐blind placebo‐controlled trial

• Published in: Phytotherapy research 2020-12, Vol.34 (12), p.3180-3188
• Main Authors: Shadnoush, Mahdi, Zahedi, Hoda, Norouzy, Abdolreza, Sahebkar, Amirhossein, Sadeghi, Omid, Najafi, Atabak, Hosseini, Saeed, Qorbani, Mostafa, Ahmadi, Arezoo, Ardehali, Seyed Hossein, Hosseinzadeh‐Attar, Mohammad Javad
• Format: Article
• Language: English
• Subjects: Adipokines - blood; Adiponectin; Adiponectin - blood; Adolescent; Adult; Aged; Alkaloids - administration & dosage; Benzodioxoles - administration & dosage; Clinical trials; Critical Illness - therapy; curcumin; Curcumin - administration & dosage; Curcumin - pharmacology; Diarylheptanoids - administration & dosage; Diarylheptanoids - pharmacology; Dietary Supplements; Double-Blind Method; Double-blind studies; Enteral nutrition; Female; Head injuries; Humans; intensive care unit; Iran; Leptin; Leptin - blood; Male; Middle Aged; Nutrition; Piperidines - administration & dosage; Piperine; Placebos; Polyunsaturated Alkamides - administration & dosage; Reduction; Serum levels; Traumatic brain injury; Young Adult
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.6749

Previous studies have shown a beneficial effect of curcuminoids supplementation on serum concentrations of adipokines; however, there are no published studies that have examined this effect among critically ill patients. We aimed to assess the effects of supplementation with curcuminoids on serum concentrations of leptin and adiponectin in critically ill patients with traumatic brain injury (TBI). In this trial, 62 critically ill patients with TBI, aged 18–65 years, were randomly allocated to receive either 500 mg/day curcuminoids (co‐administered with 5 mg/day piperine) or matched placebo for 7 days. Patients in both intervention groups received routine treatments for TBI as well as enteral nutrition. Serum concentrations of leptin and adiponectin were measured at baseline and at the end of trial. We found a significant reduction in serum levels of leptin in both curcuminoids (47.1%) and placebo (22.8%) groups; though the magnitude of reduction was greater in the former (p  .05). Supplementation with curcumioinds significantly reduced serum levels of leptin but had no significant effect on adiponectin levels in critically ill patients with TBI. Further clinical trials, particularly those with a long‐term period, are needed to confirm our findings.