Association between biomarkers and house dust mite sublingual immunotherapy in allergic asthma

Background House dust mite (HDM) sublingual immunotherapy (SLIT) has demonstrated efficacy in clinical trials of patients with asthma. Airway inflammation is a characteristic of respiratory allergy, but its relationship to SLIT remains unclear. Objective We evaluate the association between clinical...

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Bibliographic Details
Published in:Clinical and experimental allergy 2020-09, Vol.50 (9), p.1035-1043
Main Authors: Hoshino, Makoto, Akitsu, Kenta, Kubota, Kengo, Ohtawa, Junichi
Format: Article
Language:English
Subjects:
Allergies
Asthma
Biomarkers
Clinical trials
Drug therapy
house dust mite
Immunoglobulin E
Immunotherapy
Leukocytes (eosinophilic)
Nitric oxide
Oral administration
Respiratory function
Respiratory tract diseases
rhinitis
sublingual immunotherapy
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Summary:Background House dust mite (HDM) sublingual immunotherapy (SLIT) has demonstrated efficacy in clinical trials of patients with asthma. Airway inflammation is a characteristic of respiratory allergy, but its relationship to SLIT remains unclear. Objective We evaluate the association between clinical outcomes with pulmonary function and biomarkers in before and after HDM SLIT (UMIN Number 000022390). Methods One hundred twelve patients with asthma sensitized to HDM were randomized to add‐on 6 standardized quality (SQ)‐HDM SLIT to pharmacotherapy or pharmacotherapy alone for 48 weeks. At baseline and end of study, biomarkers, blood eosinophils, serum IgE, serum periostin, fractional exhaled nitric oxide (FeNO), and spirometry and clinical symptoms were measured. Association between biomarkers and an increase in FEV1 of 120 mL or greater were analysed. Results Sublingual immunotherapy (SLIT) demonstrated a significant reduction of serum periostin (P 
ISSN:0954-7894
1365-2222
DOI:10.1111/cea.13686