Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma

We developed a mixing medical device by attaching Shirasu porous glass Millipore membrane to prepare water-in-oil-in-water (WOW) emulsion in a shorter time to be applied as 10B-entrapped WOW emulsion for hepatocellular carcinoma (HCC) treatment. Single-dose toxicity studies by intra-arterial injecti...

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Published in:Applied radiation and isotopes 2020-09, Vol.163, p.109202-109202, Article 109202
Main Authors: Yanagie, Hironobu, Yanagawa, Masashi, Higuchi, Tsuyoshi, Mizumachi, Ryouji, Fujihara, Mitsuteru, Morishita, Yasuyuki, Sakurai, Yuriko, Mouri, Kikue, Dewi, Novriana, Nonaka, Yasumasa, Shinohara, Atsuko, Matsukawa, Takehisa, Kubota, Ayano, Yokoyama, Kazuhito, Suzuki, Minoru, Masunaga, Shin-ichiro, Sakurai, Yohinori, Tanaka, Hiroki, Ono, Koji, Yamauchi, Haruo, Ono, Minoru, Nakajima, Jun, Higashi, Shushi, Takahashi, Hiroyuki
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Language:English
Subjects:
BNCT
Hepatocellular carcinoma
Intra-arterial injection
Mixing medical device
WOW emulsion
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cited_by cdi_FETCH-LOGICAL-c341t-f43c368c8270bfb210864902383e370517ba02fc92a834716037d9081a1f67053
cites cdi_FETCH-LOGICAL-c341t-f43c368c8270bfb210864902383e370517ba02fc92a834716037d9081a1f67053
container_end_page 109202
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container_title Applied radiation and isotopes
container_volume 163
creator Yanagie, Hironobu
Yanagawa, Masashi
Higuchi, Tsuyoshi
Mizumachi, Ryouji
Fujihara, Mitsuteru
Morishita, Yasuyuki
Sakurai, Yuriko
Mouri, Kikue
Dewi, Novriana
Nonaka, Yasumasa
Shinohara, Atsuko
Matsukawa, Takehisa
Kubota, Ayano
Yokoyama, Kazuhito
Suzuki, Minoru
Masunaga, Shin-ichiro
Sakurai, Yohinori
Tanaka, Hiroki
Ono, Koji
Yamauchi, Haruo
Ono, Minoru
Nakajima, Jun
Higashi, Shushi
Takahashi, Hiroyuki
description We developed a mixing medical device by attaching Shirasu porous glass Millipore membrane to prepare water-in-oil-in-water (WOW) emulsion in a shorter time to be applied as 10B-entrapped WOW emulsion for hepatocellular carcinoma (HCC) treatment. Single-dose toxicity studies by intra-arterial injection of 10BSH-entrapped WOW were performed in rabbits and pig, and no side effects were observed. We hope to proceed to the preclinical and clinical studies for further evaluation of 10B compound as multidisciplinary treatments for HCC. •We developed new mixing medical device to shorten preparation time of WOW emulsion.•No side effects observed after 10BSH-WOW single-dose toxicity study in rabbit and pig.•10BSH-WOW emulsion could serve to deliver and retain boron atoms into cancer cells.
doi_str_mv 10.1016/j.apradiso.2020.109202
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subjects BNCT
Hepatocellular carcinoma
Intra-arterial injection
Mixing medical device
WOW emulsion
title Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma
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