Proof of principle of a novel co‐pulsating intra‐ventricular membrane pump

In this proof of principle study, we investigated the effectiveness and safety of hemodynamic support with the Intra‐Ventricular Membrane Pump (IVMP). The IVMP was implanted into the apex of the left ventricle. Hemodynamic assessment was performed in six ex vivo beating porcine hearts (PhysioHeart p...

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Bibliographic Details
Published in:Artificial organs 2020-12, Vol.44 (12), p.1267-1275
Main Authors: Dort, Daniël I. M., Thannhauser, Jos, Gommans, Frank D. H., Ten Cate, Tim J., Duncker, Dirk J., Suryapranata, Harry, Morshuis, Wim J., Geuzebroek, Guillaume S. C.
Format: Article
Language:English
Subjects:
Blood pressure
Carbon monoxide
Cardiac output
cardiogenic shock
Catheters
ex vivo beating heart
Flow mapping
Heart valves
Hemodynamics
mechanical circulatory support
Medical instruments
Membranes
Mercury
Mitral valve
Parameters
pulsatile flow
Ventricle
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Summary:In this proof of principle study, we investigated the effectiveness and safety of hemodynamic support with the Intra‐Ventricular Membrane Pump (IVMP). The IVMP was implanted into the apex of the left ventricle. Hemodynamic assessment was performed in six ex vivo beating porcine hearts (PhysioHeart platform). The cardiac output (CO), mean arterial pressure (MAP), coronary flow (CF) and pulse pressure (PP) were obtained before and during IVMP support and reported as means ± standard deviations. In two additional visualization experiments, the integrity of the mitral valve was assessed during IVMP support. We found a significant increase of the CO (+1.4 ± 0.2 L/min, P 
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.13757