Impact of PNPLA3 (rs738409‐G) polymorphism on post‐transplant outcomes after liver transplantation for alcohol‐related liver disease

• Published in: Clinical transplantation 2020-09, Vol.34 (9), p.e14011-n/a
• Main Authors: Yoo, Tae, Lee, Kwang‐Woong, Yi, Nam‐Joon, Hong, Suk Kyun, Lee, Jeong‐Moo, Kim, Hyeyoung, Lim, Jieun, Seo, Sooin, Suh, Kyung‐Suk
• Format: Article
• Language: English
• Subjects: alcohol recidivism; alcoholic liver disease; Humans; Lipase - genetics; Liver Diseases, Alcoholic - genetics; Liver Diseases, Alcoholic - surgery; Liver Transplantation; Membrane Proteins - genetics; Polymorphism, Single Nucleotide - genetics; Retrospective Studies; Risk Factors
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/ctr.14011

Introduction We aimed to evaluate the association between PNPLA3 polymorphism and post‐liver transplantation (LT) outcomes related to alcohol relapse (AR). Method We retrospectively analyzed data from patients receiving LT for alcoholic liver disease (ALD) from 04/2014 to 12/2017. Liver‐related clinical outcomes were assessed by the gamma‐glutamyltransferase (GGT) level and alcohol‐related liver failure (ARLF). Genotyping was performed using prospectively collected DNA samples in both donors and recipients. Results A total of 83 recipients were enrolled. Post‐LT AR occurred in 31 patients (37.3%). Thirty‐one patients (14 AR, 9 abstainers) showed elevated GGT levels, and 3 AR patients experienced ARLF. In the multivariate analysis, rs738409 G allele carrier and heavy drinking (HRAR score ≥ 4) were independent risk factors for elevated GGT levels (odds ratio [OR] = 8.69, P