Low Triglyceride Levels are Associated with Unfavorable Outcomes in Patients with Spontaneous Intracerebral Hemorrhage

Background and Aims The relationship between serum lipid level and clinical outcome after spontaneous intracerebral hemorrhage (ICH) remains controversial. We sought to evaluate the association of serum lipid levels with clinical outcomes in patients with ICH. Methods Data on consecutive patients ho...

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Bibliographic Details
Published in:Neurocritical care 2021-02, Vol.34 (1), p.218-226
Main Authors: Liu, Qian, Zhao, Wenjuan, Xing, Yonghong, Hong, Yan, Zhou, Guanen
Format: Article
Language:English
Subjects:
Antihypertensives
Blood
Creatinine
Critical Care Medicine
Drug use
Hematoma
Hemorrhage
High density lipoprotein
Hypertension
Intensive
Internal Medicine
Ischemia
Lipids
Medicine
Medicine & Public Health
Neurology
Neurosurgery
Original Work
Risk factors
Standard deviation
Stroke
Triglycerides
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Summary:Background and Aims The relationship between serum lipid level and clinical outcome after spontaneous intracerebral hemorrhage (ICH) remains controversial. We sought to evaluate the association of serum lipid levels with clinical outcomes in patients with ICH. Methods Data on consecutive patients hospitalized with spontaneous ICH were prospectively collected from May 2005 to May 2018 and retrospectively analyzed. Following clinical and demographic data, age and gender, risk factors, serum lipid levels [total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol] and the outcomes were analyzed. Results A total of 1451 patients with ICH (mean age, 60.41 ± 12.3 years; 32.6% women) was evaluated. Although admission TG levels were associated with the outcomes at hospital discharge and 3 months in initial univariate analyses, the former association did not retain its statistical significance in multivariate logistic regression analyses adjusting for potential confounders. However, lower admission TG levels were independently associated ( p  = 0.045) with a higher likelihood of 12-month unfavorable outcomes (odds ratio 0.91, 95% confidence interval 0.83–0.99) in multivariate logistic regression models. Conclusions Low TG levels at hospital admission were an independent predictor for unfavorable long-term outcomes in patients with spontaneous ICH. The exact mechanisms of the association need further investigations.
ISSN:1541-6933
1556-0961
DOI:10.1007/s12028-020-01023-0