A review on ameliorative green nanotechnological approaches in diabetes management

• Published in: Biomedicine & pharmacotherapy 2020-07, Vol.127, p.110198-110198, Article 110198
• Main Authors: Bhardwaj, Monika, Yadav, Poonam, Dalal, Sunita, Kataria, Sudhir Kumar
• Format: Article
• Language: English
• Subjects: Diabetes; Diabetes Mellitus - drug therapy; Disease Management; Drug Compounding - methods; glucose uptake assays; Humans; insulin; nanoparticles; Nanotechnology - methods; secondary metabolites; α-amylase
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2020.110198

Managerial pathways showing anti-diabetic action of different metallic nanoparticles (A) flavonoids and glycosides coated MNPs (B) Terpenoids and flavonoids coated MNPs (C) MNPs inhibits the α-amylase and α-glucosidase. [Display omitted] •Diabetes mellitus is a chronic metabolic disorder due to hyperglycaemic condition mainly due to insufficient insulin secretion or body fails to respond to secreted insulin from pancreatic cells and is the third cause of death worldwide after cardiovascular diseases and cancer.•Nanotechnology is an emerging area in pharmaceutical sciences as nanoparticles mainly silver, zinc oxide, gold, chitosan etc synthesized using different plant resources as various secondary metabolites like saponins, flavonoids, steroids, alkaloids, and tannins, increases the efficacy of drugs by their target specific activity and play pivotal role in management of disease.•The green metallic nanotechnological approaches revealed antibiabetic potential and assisted in understanding various therapeutic processes and manipulated significantly regulatory mechanism/s pertaining to management of diabetes through pancreatic α-amylase, intestinal α-glucosidase, insulin secretion or its action, glucose uptake, receptor affinity and other biochemical/histological parameters in different in vivo and in vitro systems.•The furtherance of nanotechnological approaches about exploration of herbal chemical potential may lead to consideration of certain novel magic drug molecules for better management of diabetes and other diseases.•The nanotechnology is expanding its wings to cater its beneficial effects in fields like drug delivery system, cosmetics, agriculture, tissue engineering, diagnostic systems, and management of various diseases. Diabetes mellitus is a chronic metabolic disorder which results in increase of blood glucose level mainly due to insufficient insulin secretion or body fails to respond to secreted insulin from pancreatic cells. Diabetes is mainly the third cause of death worldwide after cardiovascular diseases and cancer. Nanotechnology is an emerging area in pharmaceutical sciences as nanoparticles are reported to increase the efficacy of drugs derived from plant resources by their target specific activity. The nanomaterials synthesized from plant resources have regulatory potential in control of certain diseases with minimum or no side effects. The review focuses on the reported antidiabetic potential of different metallic and other nanoparticl