A Sex-Based Analysis From the RAIN-CARDIOGROUP VII Study (VeRy Thin Stents for Patients With Left MAIn or BifurcatioN in Real Life) on Left Main Stenting

• Published in: The Journal of invasive cardiology 2020-09, Vol.32 (9), p.342
• Main Authors: Trabattoni, Daniela, Gili, Sebastiano, Teruzzi, Giovanni, Omedè, Pierluigi, Cerrato, Enrico, Templin, Christian, Capodanno, Davide, Lüscher, Thomas, Ryan, Nicola, Venuti, Giuseppe, Montabone, Andrea, Wojakowski, Wojciech, Rognoni, Andrea, Helft, Gerard, Gallo, Diego, Biolè, Carlo Alberto, Parma, Radoslaw, De Luca, Leonardo, Figini, Filippo, Mitomo, Satoru, Mattesini, Alessio, Boccuzzi, Giacomo, Quadri, Giorgio, Wańha, Wojciech, Smolka, Grzegorz, Huczek, Zenon, Chieffo, Alaide, Nuñez-Gil, Ivan, Morbiducci, Umberto, Iannaccone, Mario, di Mario, Carlo, Moretti, Claudio, D'Amico, Maurizio, Sheiban, Imad, Escaned, Javier, D'Ascenzo, Fabrizio
• Format: Article
• Language: English
• Subjects: Coronary Artery Disease - surgery; Female; Humans; Male; Percutaneous Coronary Intervention - adverse effects; Prosthesis Design; Registries; Risk Factors; Stents - adverse effects; Treatment Outcome
• ISSN: 1557-2501; 1557-2501
• DOI: 10.25270/jic/20.00077

There is a lack of data on clinical outcomes of percutaneous coronary intervention (PCI) with ultrathin stents on unprotected left main (ULM) coronary artery comparing women and men. All patients treated with ULM-PCI with ultrathin stents (struts ≤81 μm) enrolled in the RAIN-CARDIOGROUP VII study were analyzed according to a sex-assessment evaluation. Major adverse cardiovascular event (MACE, a composite of all-cause death, myocardial infarction, target-lesion revascularization [TLR], and stent thrombosis) was the primary endpoint, whereas single components of MACE were the secondary endpoints. Out of a cohort of 793 patients, a total of 172 women (21.7%) and 621 men (78.3%) were included. Compared with men, women were older and less frequently smokers, had more frequently a history of previous PCI, and presented more frequently with an acute coronary syndrome. Among women, ostial lesions were more prevalent and mean stent diameter was lower compared with men. After 13.4 months (range, 8.4-21.6 months), 32 women (18.6%) and 106 men (17.1%) experienced MACE (P=.64). Censoring follow-up data at 3 years, no differences were observed in MACE (16.9 vs 14.7 per 100•patient-years; log-rank P=.61) and their single components between women and men. At multivariate analysis, chronic kidney disease (hazard ratio [HR], 1.91: 95% confidence interval [CI], 1.23 to -2.95; P