New treatment strategy for severe heart failure: combination of ventricular assist device and regenerative therapy

Heart transplantation and ventricular assist device for the patients with end-stage heart failure are limited by availability and durability due to limited donor or device-related complication. Thus, complementation or a new alternative is needed for the treatment of severe heart failure. Based on t...

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Bibliographic Details
Published in:Journal of artificial organs 2021-03, Vol.24 (1), p.1-5
Main Authors: Domae, Keitaro, Miyagawa, Shigeru, Toda, Koichi, Sawa, Yoshiki
Format: Article
Language:English
Subjects:
Biomedical Engineering and Bioengineering
Cardiac Surgery
Cardiomyopathy
Congestive heart failure
Durability
Heart failure
Heart transplantation
Ischemia
Medicine
Medicine & Public Health
Myoblasts
Nephrology
Patients
Review
Therapy
Transplantation
Ventricle
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Summary:Heart transplantation and ventricular assist device for the patients with end-stage heart failure are limited by availability and durability due to limited donor or device-related complication. Thus, complementation or a new alternative is needed for the treatment of severe heart failure. Based on the results of basic experiments, we applied skeletal myoblast cell sheet transplantation in a clinical setting using cell-sheet methods with temperature-responsive dish for the treatment of heart failure patient from 2007. After confirming the safety of this treatment, we started a clinical trial of myoblast cell sheet transplantation as sole therapy. According to these results, in 2015, myoblast cell sheet transplantation with ischemic cardiomyopathy was approved by the Japanese government and now this treatment was covered by Japanese health insurance. Here we report our approach and future perspective of cardiac regenerative therapy using this new treatment method for severe heart failure including new strategy incorporating regenerative therapy in the conventional treatment of heart failure including VAD and heart transplantation.
ISSN:1434-7229
1619-0904
DOI:10.1007/s10047-020-01185-w