Fabrication of Paper-based Microfluidic Devices Using a Laser Beam Scanning Technique

This paper describes a novel method for fabricating paper-based microfluidic devices using a laser beam scanning technique. Cellulose chromatography papers were treated with octadecyltrichlorosilane (OTS) to make them entirely hydrophobic. A photoacid generator (CPI-410S) was soaked into the paper,...

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Bibliographic Details
Published in:Analytical Sciences 2020/10/10, Vol.36(10), pp.1275-1278
Main Authors: HIEP, Dang Huy, TANAKA, Yuta, MATSUBARA, Hiroki, ISHIZAKA, Shoji
Format: Article
Language:English
Subjects:
Analytical Chemistry
Cellulose
Chemistry
Fabrication
Hydrophilicity
Hydrophobicity
laser beam scanning technique
Laser beams
Lasers
Microfluidic devices
Microfluidics
Paper-based microfluidic device
photoacid generator
Scanning
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Summary:This paper describes a novel method for fabricating paper-based microfluidic devices using a laser beam scanning technique. Cellulose chromatography papers were treated with octadecyltrichlorosilane (OTS) to make them entirely hydrophobic. A photoacid generator (CPI-410S) was soaked into the paper, and irradiated with a 405-nm laser beam to induce acid generating reactions. Since the silyl ether bond between cellulose and OTS was cleaved by the hydrolysis reaction, the photo-irradiated area changed to hydrophilic. By scanning the laser beam using a Galvo mirror system, arbitrary shaped hydrophilic patterns were successfully created on the paper in 50 μm resolution. To the best of our knowledge, this is the first report on the fabrication of hydrophilic channels on the OTS-treated paper using photo-induced acid generation processes coupled with the laser beam scanning technique. Quantification of nitrite was demonstrated with the paper device made by this method.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.20P196