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Selective Carbon-Carbon Bond Cleavage of Cyclopropylamine Derivatives

This review summarizes synthetic developments reported from 1987 to 2019 that exploit C-C single bond cleavage of cyclopropylamine-based systems. The synthetic and mechanistic aspects of key methodologies are highlighted, and examples where aminocyclopropanes are exploited as key intermediates in mu...

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Bibliographic Details
Published in:Chemical reviews 2021-01, Vol.121 (1), p.80-109
Main Authors: Sokolova, Olga O, Bower, John F
Format: Article
Language:English
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Summary:This review summarizes synthetic developments reported from 1987 to 2019 that exploit C-C single bond cleavage of cyclopropylamine-based systems. The synthetic and mechanistic aspects of key methodologies are highlighted, and examples where aminocyclopropanes are exploited as key intermediates in multistep synthesis are also discussed. The review encompasses cases where aminocyclopropanes participate in polar reactions, pericyclic processes, radical-based reactions, and C-C bond activations.
ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.0c00166