Emerging combination strategies with phototherapy in cancer nanomedicine

Optical techniques using developed laser and optical devices have made a profound impact on modern medicine, with "biomedical optics" becoming an emerging field. Sophisticated technologies have been developed in cancer nanomedicine, such as photothermal therapy and photodynamic therapy, am...

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Bibliographic Details
Published in:Chemical Society reviews 2020-11, Vol.49 (22), p.865-887
Main Authors: Xie, Zhongjian, Fan, Taojian, An, Jusung, Choi, Wonseok, Duo, Yanhong, Ge, Yanqi, Zhang, Bin, Nie, Guohui, Xie, Ni, Zheng, Tingting, Chen, Yun, Zhang, Han, Kim, Jong Seung
Format: Article
Language:English
Subjects:
Animals
Cancer
Cancer therapies
Combinatorial analysis
Gene therapy
Humans
Light therapy
Nanomedicine
Neoplasms - therapy
Optics
Photodynamic therapy
Phototherapy
Radiation therapy
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Summary:Optical techniques using developed laser and optical devices have made a profound impact on modern medicine, with "biomedical optics" becoming an emerging field. Sophisticated technologies have been developed in cancer nanomedicine, such as photothermal therapy and photodynamic therapy, among others. However, single-mode phototherapy cannot completely treat persistent tumors, with the challenges of relapse or metastasis remaining; therefore, combinatorial strategies are being developed. In this review, the role of light in cancer therapy and the challenges of phototherapy are discussed. The development of combinatorial strategies with other therapeutic methods, including chemotherapy, immunotherapy, gene therapy, and radiotherapy, is presented and future directions are further discussed. This review aims to highlight the significance of light in cancer therapy and discuss the combinatorial strategies that show promise in addressing the challenges of phototherapy. Based on the challenges in single-mode phototherapy, this review summarizes the significant research progress in combinatorial strategies with phototherapy.
ISSN:0306-0012
1460-4744
DOI:10.1039/d0cs00215a