Mitochondrial Transplantation: A Critical Analysis

“Mitochondrial transplantation” refers to a procedure for introducing isolated mitochondria into a damaged area of a heart or other organ. A considerable amount of data has been accumulated on the therapeutic effects of “mitochondrial transplantation” in animals with ischemic heart damage. In 2017,...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow) 2020-05, Vol.85 (5), p.636-641
Main Author: Chernyak, B. V.
Format: Article
Language:English
Subjects:
Analysis
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Calcium
Calcium - metabolism
Calcium ions
Cardiomyocytes
Clinical Trials as Topic
Damage
Discussion
Disease Models, Animal
Energy output
Health aspects
Heart Diseases - therapy
Humans
Ischemia
Life Sciences
Microbiology
Mitochondria
Mitochondria - transplantation
Mitochondria, Heart - physiology
Reperfusion Injury - therapy
Transplantation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:“Mitochondrial transplantation” refers to a procedure for introducing isolated mitochondria into a damaged area of a heart or other organ. A considerable amount of data has been accumulated on the therapeutic effects of “mitochondrial transplantation” in animals with ischemic heart damage. In 2017, the first attempts were made to apply this procedure in a clinic. The authors of the method suggest that exogenous mitochondria penetrate into cardiomyocytes, retaining functional activity, and compensate for impaired energy output of endogenous mitochondria. This hypothesis contradicts the well-known fact of loss of mitochondrial functions in the presence of high concentrations of Ca 2+ , which are characteristic of the extracellular medium. This review critically considers the possible mechanisms of the therapeutic effect of “mitochondrial transplantation”.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297920050132