Self healing hydrogels: A new paradigm immunoadjuvant for delivering peptide vaccine

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2020-10, Vol.194, p.111171-111171, Article 111171
• Main Authors: Gupta, Diksha, Gangwar, Aishwarya, Jyoti, Kiran, Sainaga Jyothi, Vaskuri G.S., Sodhi, Rupinder Kaur, Mehra, Neelesh Kumar, Singh, Shashi Bala, Madan, Jitender
• Format: Article
• Language: English
• Subjects: Antigen; Immune system; Immunoadjuvant; Self-healing hydrogel; Vaccine
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2020.111171

[Display omitted] •Self-healing hydrogels could maintain numerous cycles of autonomous healing.•Self-healing hydrogel preserves stability and integrity of encapsulated peptide.•Self-healing hydrogel well retains biological activity of encapsulated peptide. Immunoadjuvants are added to the vaccines in order to enhance and prolong the antigen specific immune responses when used in consolidation with specific vaccine antigens. This permits the use of antigen in lower quantity and allows immunization protocols practicing the vaccine with smaller doses. Self-healing hydrogels have the ability to heal the damages instinctively and reinstate its framework to ordinariness in absence of external stimuli. Moreover, self-healing hydrogel having various properties such as shear-thinning and reversible sol-gel transformation properties allow it to be readily delivered via injection. Therefore, in the present review, self- healing hydrogel is projected to be used as a carrier for sustained release of peptide and as an analogous to immunoadjuvant. The sustained release property of self-healing hydrogel may be credited to the changes in the structure in response to internal or external stimuli. In addition to the huge potential of stimuli-responsive self-healing hydrogels, they also exhibit good mechanical properties. These properties make self-healing hydrogel as a smart material in delivering the vaccines. Moreover, we have also summarized diverse range of physical and chemical reactions reported for the scale-up of self-healing hydrogels in this review.