Downregulation of Cancer-Associated lncRNAs in Peripheral Blood of Multiple Sclerosis Patients

Recent studies have shown contribution of long non-coding RNAs (lncRNAs) in the pathogenesis of immune-related disorders including multiple sclerosis (MS). Based on the role of these transcripts in the regulation of immune response, peripheral levels of lncRNAs can reflect the level of immune activa...

Full description

Saved in:
Bibliographic Details
Published in:Journal of molecular neuroscience 2020-10, Vol.70 (10), p.1533-1540
Main Authors: Safa, Amin, Taheri, Mohammad, Fallah, Hamid, Salmani, Tayyebali, Arsang-Jang, Shahram, Ghafouri-Fard, Soudeh, Omrani, Mir Davood
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Blood
Blood cancer
Cell Biology
Correlation
Immune response
Immune system
Multiple sclerosis
Neurochemistry
Neurology
Neurosciences
Non-coding RNA
Pathogenesis
Peripheral blood
Proteomics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent studies have shown contribution of long non-coding RNAs (lncRNAs) in the pathogenesis of immune-related disorders including multiple sclerosis (MS). Based on the role of these transcripts in the regulation of immune response, peripheral levels of lncRNAs can reflect the level of immune activation. In the present study, we quantified expression of four lncRNAs namely SPRY4-IT1 , HOXA-AS2 , LINC-ROR , and MEG3 in venous blood of MS patients and controls using quantitative real-time PCR method. Relative expressions of SPRY4-IT1 , HOXA-AS2 , LINC-ROR , and MEG3 were significantly lower in female MS patients compared with female healthy subjects. For MEG3 , this pattern of expression was also observed in male subjects. However, for other lncRNAs, no significant difference was detected between male patients and male controls. Expression of HOXA-AS2 was correlated with progression index ( r  = 0.36, P  
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-020-01646-0