Green and enhanced extraction of coumarins from Cortex Fraxini by ultrasound‐assisted deep eutectic solvent extraction

Green and enhanced extraction of bioactive ingredients from medicinal plants has become a hot research field, and deep eutectic solvents have been considered as a novel kind of sustainable solvents in the extraction process. In this study, hydrogen bond acceptor (choline chloride, etc.) and hydrogen...

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Bibliographic Details
Published in:Journal of separation science 2020-09, Vol.43 (17), p.3441-3448
Main Authors: Wang, Yinan, Hu, Youhui, Wang, Hui, Tong, Minghui, Gong, Yinhan
Format: Article
Language:English
Subjects:
Aqueous solutions
Choline
Cortex Fraxini
Coumarin
deep eutectic solvents
Eutectics
Fourier transforms
green extraction
Herbal medicine
Hydrogen bonds
Malic acid
Moisture content
Solvent extraction
Solvent extraction processes
Solvents
Ultrasonic imaging
Ultrasound
ultrasound assisted extraction
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Summary:Green and enhanced extraction of bioactive ingredients from medicinal plants has become a hot research field, and deep eutectic solvents have been considered as a novel kind of sustainable solvents in the extraction process. In this study, hydrogen bond acceptor (choline chloride, etc.) and hydrogen bond donor (l‐malic acid, etc.) were used to prepare different kinds of deep eutectic solvents to extract coumarins from Cortex Fraxini. The extraction conditions, including the composition and moisture content of deep eutectic solvents, extraction time, and liquid‐solid ratio, were systematically optimized basing on the extraction yield of coumarins. To further investigate the extraction mechanism, Fourier transform infrared spectroscopy was performed, and the microstructures of Cortex Fraxini powders were observed before and after extraction using scanning electron microscope. Results showed that the novel ultrasound‐assisted extraction with conditions of deep eutectic solvent containing betaine/glycerin (1:3), aqueous solution (20%), solid‐liquid ratio (15 mg/mL), and extraction time (30 min) exhibited the best extraction yields for the four target coumarins and much better extraction efficiency than with conventional solvent extractions. This suggests that the new ultrasound‐assisted deep eutectic solvent extraction could be used as a green and high‐efficient approach for extraction of the main coumarins from Cortex Fraxini.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.202000334