Monosomal karyotype is associated with poor outcomes in patients with Philadelphia chromosome–negative acute lymphoblastic leukemia receiving chemotherapy but not allogeneic hematopoietic stem cell transplantation

Monosomal karyotype (MK) is associated with poor prognosis in patients with myeloid neoplasms; however, its prognostic significance in Philadelphia chromosome–negative (Ph-negative) acute lymphoblastic leukemia (ALL) remains unclear. Data of 323 patients with Ph-negative ALL treated at Peking Univer...

Full description

Saved in:
Bibliographic Details
Published in:Annals of hematology 2020-08, Vol.99 (8), p.1833-1843
Main Authors: Li, Zongru, Lai, Yueyun, Zhang, Xiaohui, Xu, Lanping, Liu, Kaiyan, Wang, Yu, Yan, Chenhua, Jiang, Hao, Huang, Xiaojun, Jiang, Qian
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Allografts
Antineoplastic Agents - administration & dosage
Chemotherapy
Female
Hematology
Hematopoietic Stem Cell Transplantation
Humans
Incidence
Leukemia
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Neoplasm, Residual
Oncology
Original Article
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Retrospective Studies
Stem cell transplantation
Stem cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Monosomal karyotype (MK) is associated with poor prognosis in patients with myeloid neoplasms; however, its prognostic significance in Philadelphia chromosome–negative (Ph-negative) acute lymphoblastic leukemia (ALL) remains unclear. Data of 323 patients with Ph-negative ALL treated at Peking University People’s Hospital were retrospectively analyzed. MK was identified in 49 (14.8%) patients. The patients with MK had lower hemoglobin levels ( P  = 0.026), lower platelet count ( P  = 0.032), higher percentages of blasts in the peripheral blood at diagnosis ( P  = 0.008), and higher percentages of high-risk karyotypes ( P  
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-020-04155-7