Biotinylated platinum() metallacage towards targeted cancer theranostics

A biotinylated metallacage was prepared via metal-coordination-driven self-assembly, combining fluorescence, anti-cancer and targeted properties into a single entity. The metallacage was successfully employed for targeted cell imaging and therapy, offering a platform for cancer theranostics. A bioti...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-07, Vol.56 (6), p.846-8463
Main Authors: Wang, Xingchen, Su, Qi, Zhang, Zeyuan, Yang, Jin, Zhang, Yanmin, Zhang, Mingming
Format: Article
Language:English
Subjects:
Anticancer properties
Biotin - chemistry
Cancer
Cell Line, Tumor
Cell Survival - drug effects
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Coordination Complexes - therapeutic use
Fluorescence
Fluorescent Dyes - chemistry
Humans
Microscopy, Confocal
Neoplasms - diagnostic imaging
Neoplasms - drug therapy
Platinum
Platinum - chemistry
Self-assembly
Theranostic Nanomedicine
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Summary:A biotinylated metallacage was prepared via metal-coordination-driven self-assembly, combining fluorescence, anti-cancer and targeted properties into a single entity. The metallacage was successfully employed for targeted cell imaging and therapy, offering a platform for cancer theranostics. A biotinylated metallacage was prepared and employed for targeted cell imaging and therapy, offering a platform for cancer theranostics.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc03824e