Neutrophil‐to‐lymphocyte ratio as a prognostic indicator for overall and cancer‐specific survival in squamous cell carcinoma of the head and neck

Background Neutrophil‐to‐lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States. Methods We performed a...

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Bibliographic Details
Published in:Head & neck 2020-10, Vol.42 (10), p.2830-2840
Main Authors: Ferrandino, Rocco M., Roof, Scott, Garneau, Jonathan, Haidar, Yarah, Bates, Susan E., Park, Yeun‐Hee A., Bauml, Joshua M., Genden, Eric M., Miles, Brett, Sigel, Keith
Format: Article
Language:English
Subjects:
Cancer
Cell survival
Head & neck cancer
head and neck squamous cell carcinoma
Laryngeal cancer
laryngeal carcinoma
Lymphocytes
Medical prognosis
Mortality
Neutrophils
neutrophil‐to‐lymphocyte ratio
oral cavity carcinoma
oropharyngeal carcinoma
Prognosis
Solid tumors
Squamous cell carcinoma
Throat cancer
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Summary:Background Neutrophil‐to‐lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States. Methods We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5‐year overall survival and cancer‐specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates. Results The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all‐cause mortality (P 
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26329