Predictors of recurrence after total thyroidectomy plus neck dissection and radioactive iodine ablation for high‐risk papillary thyroid carcinoma

Background American Thyroid Association (ATA) proposed management guidelines for differentiated thyroid cancer, including a three‐tiered risk stratification system for structural recurrence. This study aimed to compare the various 2015 ATA criteria for the strength of association with the recurrence...

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Bibliographic Details
Published in:Journal of surgical oncology 2020-10, Vol.122 (5), p.906-913
Main Authors: Kim, Yonghan, Roh, Jong‐Lyel, Song, Dongeun, Cho, Kyung‐Ja, Choi, Seung‐Ho, Nam, Soon Yuhl, Kim, Sang Yoon
Format: Article
Language:English
Subjects:
Ablation
Ablation Techniques - methods
Adult
Disease-Free Survival
Dissection
Female
high risk
Humans
Iodine
Iodine Radioisotopes - administration & dosage
Male
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
papillary thyroid carcinoma
predictive factors
Proportional Hazards Models
recurrence
Risk Factors
Thyroid cancer
Thyroid Cancer, Papillary - pathology
Thyroid Cancer, Papillary - radiotherapy
Thyroid Cancer, Papillary - surgery
Thyroid Neoplasms - pathology
Thyroid Neoplasms - radiotherapy
Thyroid Neoplasms - surgery
Thyroidectomy
Thyroidectomy - methods
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Summary:Background American Thyroid Association (ATA) proposed management guidelines for differentiated thyroid cancer, including a three‐tiered risk stratification system for structural recurrence. This study aimed to compare the various 2015 ATA criteria for the strength of association with the recurrence of high‐risk papillary thyroid carcinoma (PTC). Study Design This study included 545 consecutive patients who underwent total thyroidectomy plus neck dissection and radioactive iodine ablation (RAI) for previously untreated high‐risk PTC. The association of recurrence‐free survival (RFS) with clinicopathological factors was evaluated by univariate and multivariate Cox proportional hazard regression analyses. Results During a follow‐up median period of 89 months, 90 (16.5%) patients had any‐site recurrence. Of the high‐risk factors, high stimulated thyroglobulin (sTg) level and >3‐cm sized lymph nodes (LNs) were significantly associated with recurrence (all P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.26090