Acute d-fenfluramine, but not fluoxetine decreases sweet intake in BALB/c, C57BL/6 and SWR inbred mouse strains

• Published in: Physiology & behavior 2020-10, Vol.224, p.113029-113029, Article 113029
• Main Authors: Mustac, Tatjana, Yuabov, Asnat, Macanian, Jason, Aminov, Sonya, Fazylov, David, Lulu, Eden Ben, Nashed, Mirna, Albakry, Ahmed, Jean-Philippe-Morisset, Bruneskidvi, Bodnar, Richard J.
• Format: Article
• Language: English
• Subjects: Murine genetic variance; Saccharin intake; Serotonin; Sucrose intake
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/j.physbeh.2020.113029

•Sweet intakes in BALB/c, C57BL/6 and SWR mice differ in pharmacological responsivity.•Acute d-fenfluramine and fluoxetine effects upon sweet intake were assessed.•Acute fluoxetine minimally affected sucrose intake in any of the three inbred strains.•Acute d-fenfluramine similarly reduced sucrose intake in all three strains.•Acute d-fenfluramine similarly reduced saccharin intake in all three strains. Dopamine, opioid and muscarinic receptor antagonists differentially reduce sucrose and saccharin intakes across inbred mouse strains. Whereas these systems stimulate sweet intake, serotonin signaling inhibits food intake. The present study examined whether fluoxetine (0.1–10 mg/kg) or d-fenfluramine (0.1–6 mg/kg) differentially inhibited sucrose or saccharin intake in BALB/c, C57BL/6 and SWR mice. Fluoxetine marginally altered sucrose intake in all strains. d-fenfluramine significantly, but quite similarly reduced (ID40) sucrose and saccharin intake in BALB/c (5.7 vs. 5.8 mg/kg), C57BL/6 (4.4 vs. 4.3 mg/kg) and SWR (4.6 vs. 5.6 mg/kg) mice, suggesting serotonin-induced inhibition of orosensory mechanisms in all three inbred mouse strains.