Depression linked to higher antibodies production against estrogenized insulin in type 1 diabetes

• Published in: International immunopharmacology 2020-09, Vol.86, p.106712-106712, Article 106712
• Main Authors: Khan, Wahid Ali, Malik, Arshi, Khan, Mohd. Wajid Ali
• Format: Article
• Language: English
• Subjects: 2-Hydroxyestradiol; Affinity; Animals; Antibodies; Autoantibodies - biosynthesis; Autoantibodies - chemistry; Autoantibodies - immunology; Autoantibodies - isolation & purification; Binding; Depression; Depression - blood; Depression - complications; Depression - immunology; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - immunology; ELISA; Enzyme-Linked Immunosorbent Assay; Estrogens, Catechol - blood; Estrogens, Catechol - chemistry; Estrogens, Catechol - immunology; Female; Humans; Immunologic Factors - blood; Inflammation; Insulin; Insulin Resistance - immunology; Male; Middle Aged; Titration; Type 1 Diabetes
• ISSN: 1567-5769; 1878-1705
• DOI: 10.1016/j.intimp.2020.106712

•Depression linked to higher antibodies production against estogenized insulin in T1D.•Depression enhance the release of IL-1β and IL-17 in T1D.•Depression generates inflammatory conditions in T1D. Depression has been commonly associated with type 1 diabetes (T1D) and insulin covalently modified with catecholestrogens (CEs) was found in serum of these T1D patients. This study aimed to know whether depression link to higher antibodies against estrogenized insulin in T1D. ELISA (direct binding and competition) and quantitative precipitin titration were used to detect antibodies and their affinities against estrogenized insulin in the serum of 66 depressed T1D (DT1D) patients (out of 110 T1D) and 41 control subjects. Antibodies from DT1D patients showed high binding specificity to estrogenized insulin (2-hydroestradiol-insulin; 2-OHE2-Ins) in comparison to overall T1D patients (p