Limited usefulness of resting hemodynamic assessments in predicting exercise capacity in hypertensive patients

• Published in: Journal of human hypertension 2021-07, Vol.35 (7), p.613-620
• Main Authors: Kurpaska, Małgorzata, Krzesiński, Paweł, Gielerak, Grzegorz, Uziębło-Życzkowska, Beata
• Format: Article
• Language: English
• Subjects: 692/308/2779/109; 692/700/139; Anaerobic threshold; Blood pressure; Body mass index; Cardiology; Clinical medicine; Echocardiography; Ejection fraction; Epidemiology; Exercise; Exercise tests; Health Administration; Health aspects; Heart; Hemodynamics; Hypertension; Laboratories; Medicine; Medicine & Public Health; Patients; Physiological aspects; Prognosis; Public Health; Ventricle
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/s41371-020-0373-x

Reliable assessments of reduced exercise capacity based on resting tests are one of the major challenges in clinical practice. The aim of this study was to evaluate the relationship between hemodynamic parameters obtained via resting tests (echocardiography and impedance cardiography (ICG)) and objective parameters of exercise capacity assessed via cardiopulmonary exercise testing and exercise ICG in patients with controlled arterial hypertension (AH). The left ventricular ejection fraction (LVEF), global longitudinal strain (GLS), diastolic function parameters (e′, E/A, E/e′), cardiac output (CO), stroke volume (SV), and systemic vascular resistance index were evaluated for any correlations with selected parameters of exercise capacity, such as peak oxygen uptake (VO 2 ) and peak CO in 93 people with AH (mean age 54 years, 47 women). Statistically relevant correlations occurred between indices of exercise capacity (peak VO 2 ; peak CO) and only the following hemodynamic parameters: diastolic blood pressure ( R  = 0.23, p  = 0.026; R  = 0.24, p  = 0.021; respectively), e′ ( R  = 0.32, p  = 0.002; R  = 0.24, p  = 0.027), E/e′ ( R  = 0.35, p