Sex-specific relationships between patterns of ventricular remodelling and clinical outcomes

Abstract Aims Left ventricular hypertrophy (LVH) is the most common form of myocardial remodelling and predicts adverse outcomes in patients with coronary artery disease (CAD). However, sex-specific prevalence and prognostic significance of LVH patterns are poorly understood. We investigated the sex...

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Published in:European heart journal cardiovascular imaging 2020-09, Vol.21 (9), p.983-990
Main Authors: Miller, Robert J H, Mikami, Yoko, Heydari, Bobak, Wilton, Stephen B, James, Matthew T, Howarth, Andrew G, White, James A, Lydell, Carmen P
Format: Article
Language:English
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Summary:Abstract Aims Left ventricular hypertrophy (LVH) is the most common form of myocardial remodelling and predicts adverse outcomes in patients with coronary artery disease (CAD). However, sex-specific prevalence and prognostic significance of LVH patterns are poorly understood. We investigated the sex-specific influence of LVH pattern on clinical outcomes in patients undergoing cardiovascular magnetic resonance (CMR) and coronary angiography following adjustment for co-morbidities including CAD burden. Methods and results Patients undergoing CMR and coronary angiography between 2005 and 2013 were included. Volumetric measurements of left ventricular (LV) mass with classification of concentric vs. eccentric remodelling patterns were determined from CMR cine images. Multivariable Cox analysis was performed to assess independent associations with the primary outcome of all-cause mortality. In total, 3754 patients were studied (mean age 59.3 ± 13.1 years), including 1039 (27.7%) women. Women were more likely to have concentric remodelling (8.1% vs. 2.1%, P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jeaa164