FeCl3‑Mediated Synthesis of 2‑(Trifluoromethyl)quinazolin-4(3H)‑ones from Isatins and Trifluoroacetimidoyl Chlorides

An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)­quinazolin-4­(3H)-ones has been developed. This transformation employs readily available isatins and trifluoroacetimidoyl chlorides as the starting materials, providing a faci...

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Bibliographic Details
Published in:Organic letters 2020-07, Vol.22 (14), p.5567-5571
Main Authors: Wang, Le-Cheng, Du, Shiying, Chen, Zhengkai, Wu, Xiao-Feng
Format: Article
Language:English
Online Access:Get full text
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Summary:An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)­quinazolin-4­(3H)-ones has been developed. This transformation employs readily available isatins and trifluoroacetimidoyl chlorides as the starting materials, providing a facile and practical route to diverse biologically relevant quinazolin-4­(3H)-one derivatives. A plausible reaction pathway has been proposed based on the mechanistic observations.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c01927