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Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat
The present work aims to evaluate the effect of melatonin (Mel) on affective and cognitive disorders induced by chronic exposure to Cadmium (Cd). Male and female Wistar rats received either an intraperitoneal injection of saline solution NaCl (0.9%), Mel (4 mg/kg), Cd (1 mg/kg), or Cd (1 mg/kg) + Me...
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Published in: | Biological trace element research 2021-04, Vol.199 (4), p.1445-1455 |
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description | The present work aims to evaluate the effect of melatonin (Mel) on affective and cognitive disorders induced by chronic exposure to Cadmium (Cd). Male and female Wistar rats received either an intraperitoneal injection of saline solution NaCl (0.9%), Mel (4 mg/kg), Cd (1 mg/kg), or Cd (1 mg/kg) + Mel (4 mg/kg) for 8 weeks. Behavioral disorders were evaluated by different tests mainly the open field and elevated plus maze tests for anxiety-like behavior, forced swimming test (FST) for depression-like behavior, and the Y-maze and Morris water maze (MWM) tests for cognitive disorders. Thereafter, oxidative stress indices and histology of the hippocampus were evaluated. The results confirm that Cd administration has anxiogenic-like effects in both anxiety tests and depressive-like effects in the FST and leads to memory and learning disabilities in the Y-maze and MWM. We also report that Mel counteracts these neurobehavioral disorders. Biochemical assays showed that rats intoxicated with Cd significantly increased levels of nitric oxide (NO) and lipid peroxidation (LPO), while the activities of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased in the hippocampus. In contrast, Mel administration attenuates the Cd-induced changes. The histopathological studies in the hippocampus of rats also supported that Mel markedly reduced the Cd-induced neuronal loss in CA3 sub-region. Overall, our results suggest that Mel could be used to protect against Cd-induced neurobehavioral changes via its antioxidant properties in the hippocampus. The effects of Cd and Mel are sex-dependent, knowing that Cd is more harmful in males, while Mel is more protective in females. |
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Male and female Wistar rats received either an intraperitoneal injection of saline solution NaCl (0.9%), Mel (4 mg/kg), Cd (1 mg/kg), or Cd (1 mg/kg) + Mel (4 mg/kg) for 8 weeks. Behavioral disorders were evaluated by different tests mainly the open field and elevated plus maze tests for anxiety-like behavior, forced swimming test (FST) for depression-like behavior, and the Y-maze and Morris water maze (MWM) tests for cognitive disorders. Thereafter, oxidative stress indices and histology of the hippocampus were evaluated. The results confirm that Cd administration has anxiogenic-like effects in both anxiety tests and depressive-like effects in the FST and leads to memory and learning disabilities in the Y-maze and MWM. We also report that Mel counteracts these neurobehavioral disorders. Biochemical assays showed that rats intoxicated with Cd significantly increased levels of nitric oxide (NO) and lipid peroxidation (LPO), while the activities of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased in the hippocampus. In contrast, Mel administration attenuates the Cd-induced changes. The histopathological studies in the hippocampus of rats also supported that Mel markedly reduced the Cd-induced neuronal loss in CA3 sub-region. Overall, our results suggest that Mel could be used to protect against Cd-induced neurobehavioral changes via its antioxidant properties in the hippocampus. The effects of Cd and Mel are sex-dependent, knowing that Cd is more harmful in males, while Mel is more protective in females.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-020-02247-z</identifier><identifier>PMID: 32613486</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antioxidant properties ; Antioxidants ; Anxiety ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Cadmium ; Catalase ; Chronic exposure ; Cognitive ability ; Disabilities ; Disorders ; Females ; Hippocampus ; Histology ; Histopathology ; Learning behaviour ; Life Sciences ; Lipid peroxidation ; Lipids ; Maze learning ; Melatonin ; Nitric oxide ; Nutrition ; Oncology ; Oxidative stress ; Peroxidation ; Saline solutions ; Sodium chloride ; Superoxide dismutase ; Swimming behavior ; Tests</subject><ispartof>Biological trace element research, 2021-04, Vol.199 (4), p.1445-1455</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a00b3860537c525fc0ca95b06d4b411bcba92aa08a0872a688c0c7c471ced1c53</citedby><cites>FETCH-LOGICAL-c375t-a00b3860537c525fc0ca95b06d4b411bcba92aa08a0872a688c0c7c471ced1c53</cites><orcidid>0000-0002-2564-3630 ; 0000-0002-4415-7654 ; 0000-0002-8016-4499</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32613486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lamtai, Mouloud</creatorcontrib><creatorcontrib>Azirar, Sofia</creatorcontrib><creatorcontrib>Zghari, Oussama</creatorcontrib><creatorcontrib>Ouakki, Sihame</creatorcontrib><creatorcontrib>El Hessni, Aboubaker</creatorcontrib><creatorcontrib>Mesfioui, Abdelhalem</creatorcontrib><creatorcontrib>Ouichou, Ali</creatorcontrib><title>Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>The present work aims to evaluate the effect of melatonin (Mel) on affective and cognitive disorders induced by chronic exposure to Cadmium (Cd). Male and female Wistar rats received either an intraperitoneal injection of saline solution NaCl (0.9%), Mel (4 mg/kg), Cd (1 mg/kg), or Cd (1 mg/kg) + Mel (4 mg/kg) for 8 weeks. Behavioral disorders were evaluated by different tests mainly the open field and elevated plus maze tests for anxiety-like behavior, forced swimming test (FST) for depression-like behavior, and the Y-maze and Morris water maze (MWM) tests for cognitive disorders. Thereafter, oxidative stress indices and histology of the hippocampus were evaluated. The results confirm that Cd administration has anxiogenic-like effects in both anxiety tests and depressive-like effects in the FST and leads to memory and learning disabilities in the Y-maze and MWM. We also report that Mel counteracts these neurobehavioral disorders. Biochemical assays showed that rats intoxicated with Cd significantly increased levels of nitric oxide (NO) and lipid peroxidation (LPO), while the activities of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased in the hippocampus. In contrast, Mel administration attenuates the Cd-induced changes. The histopathological studies in the hippocampus of rats also supported that Mel markedly reduced the Cd-induced neuronal loss in CA3 sub-region. Overall, our results suggest that Mel could be used to protect against Cd-induced neurobehavioral changes via its antioxidant properties in the hippocampus. The effects of Cd and Mel are sex-dependent, knowing that Cd is more harmful in males, while Mel is more protective in females.</description><subject>Antioxidant properties</subject><subject>Antioxidants</subject><subject>Anxiety</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Cadmium</subject><subject>Catalase</subject><subject>Chronic exposure</subject><subject>Cognitive ability</subject><subject>Disabilities</subject><subject>Disorders</subject><subject>Females</subject><subject>Hippocampus</subject><subject>Histology</subject><subject>Histopathology</subject><subject>Learning behaviour</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Maze learning</subject><subject>Melatonin</subject><subject>Nitric oxide</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Oxidative 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Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat</title><author>Lamtai, Mouloud ; Azirar, Sofia ; Zghari, Oussama ; Ouakki, Sihame ; El Hessni, Aboubaker ; Mesfioui, Abdelhalem ; Ouichou, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a00b3860537c525fc0ca95b06d4b411bcba92aa08a0872a688c0c7c471ced1c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidant properties</topic><topic>Antioxidants</topic><topic>Anxiety</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Cadmium</topic><topic>Catalase</topic><topic>Chronic exposure</topic><topic>Cognitive ability</topic><topic>Disabilities</topic><topic>Disorders</topic><topic>Females</topic><topic>Hippocampus</topic><topic>Histology</topic><topic>Histopathology</topic><topic>Learning 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Abdelhalem</au><au>Ouichou, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>199</volume><issue>4</issue><spage>1445</spage><epage>1455</epage><pages>1445-1455</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>The present work aims to evaluate the effect of melatonin (Mel) on affective and cognitive disorders induced by chronic exposure to Cadmium (Cd). Male and female Wistar rats received either an intraperitoneal injection of saline solution NaCl (0.9%), Mel (4 mg/kg), Cd (1 mg/kg), or Cd (1 mg/kg) + Mel (4 mg/kg) for 8 weeks. Behavioral disorders were evaluated by different tests mainly the open field and elevated plus maze tests for anxiety-like behavior, forced swimming test (FST) for depression-like behavior, and the Y-maze and Morris water maze (MWM) tests for cognitive disorders. Thereafter, oxidative stress indices and histology of the hippocampus were evaluated. The results confirm that Cd administration has anxiogenic-like effects in both anxiety tests and depressive-like effects in the FST and leads to memory and learning disabilities in the Y-maze and MWM. We also report that Mel counteracts these neurobehavioral disorders. Biochemical assays showed that rats intoxicated with Cd significantly increased levels of nitric oxide (NO) and lipid peroxidation (LPO), while the activities of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased in the hippocampus. In contrast, Mel administration attenuates the Cd-induced changes. The histopathological studies in the hippocampus of rats also supported that Mel markedly reduced the Cd-induced neuronal loss in CA3 sub-region. Overall, our results suggest that Mel could be used to protect against Cd-induced neurobehavioral changes via its antioxidant properties in the hippocampus. 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subjects | Antioxidant properties Antioxidants Anxiety Biochemistry Biomedical and Life Sciences Biotechnology Cadmium Catalase Chronic exposure Cognitive ability Disabilities Disorders Females Hippocampus Histology Histopathology Learning behaviour Life Sciences Lipid peroxidation Lipids Maze learning Melatonin Nitric oxide Nutrition Oncology Oxidative stress Peroxidation Saline solutions Sodium chloride Superoxide dismutase Swimming behavior Tests |
title | Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat |
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