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Echo Time‐Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics
Background Noninvasive monitoring of early abnormalities and therapeutic intervention in cystic fibrosis (CF) lung disease using MRI is important. Lung T1 mapping has shown potential for local functional imaging without contrast material. Recently, it was discovered that observed lung T1 depends on...
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| Published in: | Journal of magnetic resonance imaging 2020-12, Vol.52 (6), p.1645-1654 |
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| container_title | Journal of magnetic resonance imaging |
| container_volume | 52 |
| creator | Triphan, Simon M.F. Stahl, Mirjam Jobst, Bertram J. Sommerburg, Olaf Kauczor, Hans‐Ulrich Schenk, Jens‐Peter Alrajab, Abdulsattar Eichinger, Monika Mall, Marcus A. Wielpütz, Mark O. |
| description | Background
Noninvasive monitoring of early abnormalities and therapeutic intervention in cystic fibrosis (CF) lung disease using MRI is important. Lung T1 mapping has shown potential for local functional imaging without contrast material. Recently, it was discovered that observed lung T1 depends on the measurement echo time (TE).
Purpose
To examine TE‐dependence of observed T1 in patients with CF and its correlation with clinical metrics.
Study Type
Prospective.
Population
In all, 75 pediatric patients with CF (8.6 ± 6.1 years, range 0.1–23 years), with 32 reexamined after 1 year.
Field Strength/Sequence
Patients were examined at 1.5T using an established MRI protocol and a multiecho inversion recovery 2D ultrashort echo time (UTE) sequence for T1(TE) mapping at five TEs including TE1 = 70 μs.
Assessment
Morphological and perfusion MRI were assessed by a radiologist (M.W.) with 11 years of experience using an established CF‐MRI scoring system. T1(TE) was quantified automatically. Clinical data including spirometry (FEV1pred%) and lung clearance index (LCI) were collected.
Statistical Tests
T1(TE) was correlated with the CF‐MRI score, clinical data, and LCI.
Results
T1(TE) showed a different curvature in CF than in healthy adults: T1 at TE1 was shorter in CF (1157 ms ± 73 ms vs. 1047 ms ± 70 ms, P |
| doi_str_mv | 10.1002/jmri.27271 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_miscellaneous_2419716072</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2419716072</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2091-9c4576dfba3e4af55409d34a03203b87eb85a78d88a0783707ee9e7743cbeef43</originalsourceid><addsrcrecordid>eNpd0L1OwzAUBeAIgUQpLDyBJRaWFP8lTkYUWihqVYSKGCMnuaGuEju1E1A3HoFn5ElIfyame4ZPR1fH864JHhGM6d26tmpEBRXkxBuQgFKfBlF42mccMJ9EWJx7F86tMcZxzIOBtxnnK4OWqobf758HaEAXoHNApkSLzIH9hALNOv2BlgQpjV5kq0C3Dr2rdoWSrWtVjiYqs8Yph6QuUGKshapnRh9RpbTKZYXm0FqVu0vvrJSVg6vjHXpvk_EyefJni8dpcj_zG4pj4sc5D0RYlJlkwGUZBBzHBeMSM4pZFgnIokCKqIgiiUXEBBYAMQjBWZ4BlJwNvdtDb2PNpgPXprVyOVSV1GA6l1JOYkFCLGhPb_7Rtems7r_rVUhIGBIuekUO6ktVsE0bq2pptynB6W76dDd9up8-fZ6_TveJ_QGhC3mC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2461166147</pqid></control><display><type>article</type><title>Echo Time‐Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Triphan, Simon M.F. ; Stahl, Mirjam ; Jobst, Bertram J. ; Sommerburg, Olaf ; Kauczor, Hans‐Ulrich ; Schenk, Jens‐Peter ; Alrajab, Abdulsattar ; Eichinger, Monika ; Mall, Marcus A. ; Wielpütz, Mark O.</creator><creatorcontrib>Triphan, Simon M.F. ; Stahl, Mirjam ; Jobst, Bertram J. ; Sommerburg, Olaf ; Kauczor, Hans‐Ulrich ; Schenk, Jens‐Peter ; Alrajab, Abdulsattar ; Eichinger, Monika ; Mall, Marcus A. ; Wielpütz, Mark O.</creatorcontrib><description>Background
Noninvasive monitoring of early abnormalities and therapeutic intervention in cystic fibrosis (CF) lung disease using MRI is important. Lung T1 mapping has shown potential for local functional imaging without contrast material. Recently, it was discovered that observed lung T1 depends on the measurement echo time (TE).
Purpose
To examine TE‐dependence of observed T1 in patients with CF and its correlation with clinical metrics.
Study Type
Prospective.
Population
In all, 75 pediatric patients with CF (8.6 ± 6.1 years, range 0.1–23 years), with 32 reexamined after 1 year.
Field Strength/Sequence
Patients were examined at 1.5T using an established MRI protocol and a multiecho inversion recovery 2D ultrashort echo time (UTE) sequence for T1(TE) mapping at five TEs including TE1 = 70 μs.
Assessment
Morphological and perfusion MRI were assessed by a radiologist (M.W.) with 11 years of experience using an established CF‐MRI scoring system. T1(TE) was quantified automatically. Clinical data including spirometry (FEV1pred%) and lung clearance index (LCI) were collected.
Statistical Tests
T1(TE) was correlated with the CF‐MRI score, clinical data, and LCI.
Results
T1(TE) showed a different curvature in CF than in healthy adults: T1 at TE1 was shorter in CF (1157 ms ± 73 ms vs. 1047 ms ± 70 ms, P < 0.001), but longer at TE3 (1214 ms ± 72 ms vs. 1314 ms ± 68 ms, P < 0.001) and later TEs. The correlations of T1(TE) with patient age (ρTE1‐TE5 = −0.55, −0.44, −0.24, −0.30, −0.22), and LCI (ρTE1‐TE5 = −0.43, −0.42, −0.33, 0.27, −0.22) were moderate at ultra‐short to short TE (P < 0.001) but decreased for longer TE. Moderate but similar correlations at all TE were found with MRI perfusion score (ρTE1‐TE5 = −0.43, −0.51, −0.47, −0.46, −0.44) and FEV1pred% (ρTE1‐TE5 = +0.44, +0.44, +0.43, +0.40, +0.39) (P < 0.05).
Data Conclusion
TE should be considered when measuring lung T1, since observed differences between CF and healthy subjects strongly depend on TE. The different variation of correlation coefficients with TE for structural vs. functional metrics implies that TE‐dependence holds additional information which may help to discern effects of tissue structural abnormalities and abnormal perfusion.
Level of Evidence
2
Technical Efficacy Stage
1 J. MAGN. RESON. IMAGING 2020;52:1645–1654.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.27271</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Abnormalities ; Coefficient of variation ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Cystic fibrosis ; Field strength ; functional lung imaging ; Lung diseases ; lung T1 ; Magnetic resonance imaging ; Mapping ; Mathematical analysis ; Medical imaging ; Patients ; Perfusion ; Population studies ; Statistical analysis ; Statistical tests ; Structure-function relationships ; T1 mapping ; Time dependence ; Time measurement</subject><ispartof>Journal of magnetic resonance imaging, 2020-12, Vol.52 (6), p.1645-1654</ispartof><rights>2020 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-2068-1184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Triphan, Simon M.F.</creatorcontrib><creatorcontrib>Stahl, Mirjam</creatorcontrib><creatorcontrib>Jobst, Bertram J.</creatorcontrib><creatorcontrib>Sommerburg, Olaf</creatorcontrib><creatorcontrib>Kauczor, Hans‐Ulrich</creatorcontrib><creatorcontrib>Schenk, Jens‐Peter</creatorcontrib><creatorcontrib>Alrajab, Abdulsattar</creatorcontrib><creatorcontrib>Eichinger, Monika</creatorcontrib><creatorcontrib>Mall, Marcus A.</creatorcontrib><creatorcontrib>Wielpütz, Mark O.</creatorcontrib><title>Echo Time‐Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics</title><title>Journal of magnetic resonance imaging</title><description>Background
Noninvasive monitoring of early abnormalities and therapeutic intervention in cystic fibrosis (CF) lung disease using MRI is important. Lung T1 mapping has shown potential for local functional imaging without contrast material. Recently, it was discovered that observed lung T1 depends on the measurement echo time (TE).
Purpose
To examine TE‐dependence of observed T1 in patients with CF and its correlation with clinical metrics.
Study Type
Prospective.
Population
In all, 75 pediatric patients with CF (8.6 ± 6.1 years, range 0.1–23 years), with 32 reexamined after 1 year.
Field Strength/Sequence
Patients were examined at 1.5T using an established MRI protocol and a multiecho inversion recovery 2D ultrashort echo time (UTE) sequence for T1(TE) mapping at five TEs including TE1 = 70 μs.
Assessment
Morphological and perfusion MRI were assessed by a radiologist (M.W.) with 11 years of experience using an established CF‐MRI scoring system. T1(TE) was quantified automatically. Clinical data including spirometry (FEV1pred%) and lung clearance index (LCI) were collected.
Statistical Tests
T1(TE) was correlated with the CF‐MRI score, clinical data, and LCI.
Results
T1(TE) showed a different curvature in CF than in healthy adults: T1 at TE1 was shorter in CF (1157 ms ± 73 ms vs. 1047 ms ± 70 ms, P < 0.001), but longer at TE3 (1214 ms ± 72 ms vs. 1314 ms ± 68 ms, P < 0.001) and later TEs. The correlations of T1(TE) with patient age (ρTE1‐TE5 = −0.55, −0.44, −0.24, −0.30, −0.22), and LCI (ρTE1‐TE5 = −0.43, −0.42, −0.33, 0.27, −0.22) were moderate at ultra‐short to short TE (P < 0.001) but decreased for longer TE. Moderate but similar correlations at all TE were found with MRI perfusion score (ρTE1‐TE5 = −0.43, −0.51, −0.47, −0.46, −0.44) and FEV1pred% (ρTE1‐TE5 = +0.44, +0.44, +0.43, +0.40, +0.39) (P < 0.05).
Data Conclusion
TE should be considered when measuring lung T1, since observed differences between CF and healthy subjects strongly depend on TE. The different variation of correlation coefficients with TE for structural vs. functional metrics implies that TE‐dependence holds additional information which may help to discern effects of tissue structural abnormalities and abnormal perfusion.
Level of Evidence
2
Technical Efficacy Stage
1 J. MAGN. RESON. IMAGING 2020;52:1645–1654.</description><subject>Abnormalities</subject><subject>Coefficient of variation</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Cystic fibrosis</subject><subject>Field strength</subject><subject>functional lung imaging</subject><subject>Lung diseases</subject><subject>lung T1</subject><subject>Magnetic resonance imaging</subject><subject>Mapping</subject><subject>Mathematical analysis</subject><subject>Medical imaging</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Population studies</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Structure-function relationships</subject><subject>T1 mapping</subject><subject>Time dependence</subject><subject>Time measurement</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNpd0L1OwzAUBeAIgUQpLDyBJRaWFP8lTkYUWihqVYSKGCMnuaGuEju1E1A3HoFn5ElIfyame4ZPR1fH864JHhGM6d26tmpEBRXkxBuQgFKfBlF42mccMJ9EWJx7F86tMcZxzIOBtxnnK4OWqobf758HaEAXoHNApkSLzIH9hALNOv2BlgQpjV5kq0C3Dr2rdoWSrWtVjiYqs8Yph6QuUGKshapnRh9RpbTKZYXm0FqVu0vvrJSVg6vjHXpvk_EyefJni8dpcj_zG4pj4sc5D0RYlJlkwGUZBBzHBeMSM4pZFgnIokCKqIgiiUXEBBYAMQjBWZ4BlJwNvdtDb2PNpgPXprVyOVSV1GA6l1JOYkFCLGhPb_7Rtems7r_rVUhIGBIuekUO6ktVsE0bq2pptynB6W76dDd9up8-fZ6_TveJ_QGhC3mC</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Triphan, Simon M.F.</creator><creator>Stahl, Mirjam</creator><creator>Jobst, Bertram J.</creator><creator>Sommerburg, Olaf</creator><creator>Kauczor, Hans‐Ulrich</creator><creator>Schenk, Jens‐Peter</creator><creator>Alrajab, Abdulsattar</creator><creator>Eichinger, Monika</creator><creator>Mall, Marcus A.</creator><creator>Wielpütz, Mark O.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2068-1184</orcidid></search><sort><creationdate>202012</creationdate><title>Echo Time‐Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics</title><author>Triphan, Simon M.F. ; Stahl, Mirjam ; Jobst, Bertram J. ; Sommerburg, Olaf ; Kauczor, Hans‐Ulrich ; Schenk, Jens‐Peter ; Alrajab, Abdulsattar ; Eichinger, Monika ; Mall, Marcus A. ; Wielpütz, Mark O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2091-9c4576dfba3e4af55409d34a03203b87eb85a78d88a0783707ee9e7743cbeef43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abnormalities</topic><topic>Coefficient of variation</topic><topic>Correlation analysis</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Cystic fibrosis</topic><topic>Field strength</topic><topic>functional lung imaging</topic><topic>Lung diseases</topic><topic>lung T1</topic><topic>Magnetic resonance imaging</topic><topic>Mapping</topic><topic>Mathematical analysis</topic><topic>Medical imaging</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Population studies</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Structure-function relationships</topic><topic>T1 mapping</topic><topic>Time dependence</topic><topic>Time measurement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Triphan, Simon M.F.</creatorcontrib><creatorcontrib>Stahl, Mirjam</creatorcontrib><creatorcontrib>Jobst, Bertram J.</creatorcontrib><creatorcontrib>Sommerburg, Olaf</creatorcontrib><creatorcontrib>Kauczor, Hans‐Ulrich</creatorcontrib><creatorcontrib>Schenk, Jens‐Peter</creatorcontrib><creatorcontrib>Alrajab, Abdulsattar</creatorcontrib><creatorcontrib>Eichinger, Monika</creatorcontrib><creatorcontrib>Mall, Marcus A.</creatorcontrib><creatorcontrib>Wielpütz, Mark O.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Triphan, Simon M.F.</au><au>Stahl, Mirjam</au><au>Jobst, Bertram J.</au><au>Sommerburg, Olaf</au><au>Kauczor, Hans‐Ulrich</au><au>Schenk, Jens‐Peter</au><au>Alrajab, Abdulsattar</au><au>Eichinger, Monika</au><au>Mall, Marcus A.</au><au>Wielpütz, Mark O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Echo Time‐Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><date>2020-12</date><risdate>2020</risdate><volume>52</volume><issue>6</issue><spage>1645</spage><epage>1654</epage><pages>1645-1654</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Background
Noninvasive monitoring of early abnormalities and therapeutic intervention in cystic fibrosis (CF) lung disease using MRI is important. Lung T1 mapping has shown potential for local functional imaging without contrast material. Recently, it was discovered that observed lung T1 depends on the measurement echo time (TE).
Purpose
To examine TE‐dependence of observed T1 in patients with CF and its correlation with clinical metrics.
Study Type
Prospective.
Population
In all, 75 pediatric patients with CF (8.6 ± 6.1 years, range 0.1–23 years), with 32 reexamined after 1 year.
Field Strength/Sequence
Patients were examined at 1.5T using an established MRI protocol and a multiecho inversion recovery 2D ultrashort echo time (UTE) sequence for T1(TE) mapping at five TEs including TE1 = 70 μs.
Assessment
Morphological and perfusion MRI were assessed by a radiologist (M.W.) with 11 years of experience using an established CF‐MRI scoring system. T1(TE) was quantified automatically. Clinical data including spirometry (FEV1pred%) and lung clearance index (LCI) were collected.
Statistical Tests
T1(TE) was correlated with the CF‐MRI score, clinical data, and LCI.
Results
T1(TE) showed a different curvature in CF than in healthy adults: T1 at TE1 was shorter in CF (1157 ms ± 73 ms vs. 1047 ms ± 70 ms, P < 0.001), but longer at TE3 (1214 ms ± 72 ms vs. 1314 ms ± 68 ms, P < 0.001) and later TEs. The correlations of T1(TE) with patient age (ρTE1‐TE5 = −0.55, −0.44, −0.24, −0.30, −0.22), and LCI (ρTE1‐TE5 = −0.43, −0.42, −0.33, 0.27, −0.22) were moderate at ultra‐short to short TE (P < 0.001) but decreased for longer TE. Moderate but similar correlations at all TE were found with MRI perfusion score (ρTE1‐TE5 = −0.43, −0.51, −0.47, −0.46, −0.44) and FEV1pred% (ρTE1‐TE5 = +0.44, +0.44, +0.43, +0.40, +0.39) (P < 0.05).
Data Conclusion
TE should be considered when measuring lung T1, since observed differences between CF and healthy subjects strongly depend on TE. The different variation of correlation coefficients with TE for structural vs. functional metrics implies that TE‐dependence holds additional information which may help to discern effects of tissue structural abnormalities and abnormal perfusion.
Level of Evidence
2
Technical Efficacy Stage
1 J. MAGN. RESON. IMAGING 2020;52:1645–1654.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/jmri.27271</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2068-1184</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Coefficient of variation Correlation analysis Correlation coefficient Correlation coefficients Cystic fibrosis Field strength functional lung imaging Lung diseases lung T1 Magnetic resonance imaging Mapping Mathematical analysis Medical imaging Patients Perfusion Population studies Statistical analysis Statistical tests Structure-function relationships T1 mapping Time dependence Time measurement |
| title | Echo Time‐Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics |
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