SNP rs2043211 (p.C10X) in CARD8 Is Associated with Large-Artery Atherosclerosis Stroke in a Chinese Population

SNP rs2043211 in CARD8 was found to have significant association with ischemic stroke. This study aimed to explore the possible association between rs2043211 and large-artery atherosclerosis stroke in Chinese and explain the possible mechanism. In total, 716 large-artery atherosclerosis stroke patie...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2021-02, Vol.71 (2), p.276-283
Main Authors: Gu, Jinyu, Shen, Chong, Gu, Mengmeng, Wang, Mengmeng, Zhang, Zhizhong, Liu, Xinfeng
Format: Article
Language:English
Subjects:
Arteriosclerosis
Atherosclerosis
Bioinformatics
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cell Biology
Confidence intervals
Diabetes mellitus
Enzyme-linked immunosorbent assay
Gene expression
Genotypes
Health risks
Hypertension
Ischemia
mRNA
Neurochemistry
Neurology
Neurosciences
Protein structure
Proteomics
Risk
Secondary structure
Single-nucleotide polymorphism
Stroke
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Summary:SNP rs2043211 in CARD8 was found to have significant association with ischemic stroke. This study aimed to explore the possible association between rs2043211 and large-artery atherosclerosis stroke in Chinese and explain the possible mechanism. In total, 716 large-artery atherosclerosis stroke patients and 1088 controls were included in the study. Co-dominant, dominant, and recessive genetic models were constructed to evaluate the relationship between rs2043211 and large-artery atherosclerosis stroke risk by odds ratios with 95% confidence intervals. Stratified and interaction analyses were also done. We selected another 111 large-artery atherosclerosis stroke patients and measured the CARD8 levels in their plasma samples by enzyme-linked immunosorbent assay. Participants who carry T/T genotype have a higher risk of large-artery atherosclerosis stroke compared with those carry A/T or A/A genotypes (odds ratio = 1.35, 95% confidence intervals 1.03–1.77, P  = 0.029). The higher risk for the T/T genotype is still notable in female, people with hypertension, and people without diabetes. In the interaction analysis, compared to the non-hypertensive participants with the wild homozygote type A/A, the hypertensive participants with the A/T+T/T homozygote had 3.27-fold increased risk (odds ratio = 3.27, 95% confidence intervals 2.33–4.60). The A/A group had lower CARD8 levels in plasma than the A/T and T/T group ( P  
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-020-01647-z