Inflammation in children with neuromuscular disorders and sleep disordered breathing

Paediatric obstructive sleep apnoea is associated with systemic inflammation and co-morbidities. We assessed whether sleep disordered breathing (SDB) due to neuromuscular weakness was associated with elevated airway and systemic pro-inflammatory cytokines. Consecutive neuromuscular children (age 5–1...

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Bibliographic Details
Published in:Sleep medicine 2020-08, Vol.72, p.118-121
Main Authors: Trucco, Federica, Carruthers, Emma, Davies, Jane C., Simonds, Anita K., Bush, Andrew, Tan, Hui-Leng
Format: Article
Language:English
Subjects:
Cytokines
Hypoventilation
ICAM-1
IL-6
Neuromuscular disorders
VCAM-1
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Summary:Paediatric obstructive sleep apnoea is associated with systemic inflammation and co-morbidities. We assessed whether sleep disordered breathing (SDB) due to neuromuscular weakness was associated with elevated airway and systemic pro-inflammatory cytokines. Consecutive neuromuscular children (age 5–18years) underwent overnight full polysomnography and morning collection of serum and breath condensate, analysed for cytokines (Interleukin-10, Interleukin-6, Interleukin-1β, Tumour Necrosis Factorα, high-sensitivity C-Reactive Protein, Intercellular and Vascular Adhesion Molecules ICAM-1, VCAM-1). Cytokine levels were related to Oxygen desaturation index (ODI), desaturation>4%/h, and levels of transcutaneous carbon dioxide overnight (tcCO2≥6.7 kPa > 2% sleep). A total of 23 patients were included, median age 12.6 years (IQR 8.7–14.6). ODI>3/h was associated with higher breath and serum IL-6 (p = 0.02). Children with elevated CO2 overnight had higher ICAM-1 and VCAM-1. CO2 levels correlated with serum ICAM-1 (rs0.570, p = 0.026) and VCAM-1 (rs0.76, p = 0.001). SDB in neuromuscular children is associated with raised serum IL-6, VCAM-1, ICAM-1. This may predispose these children to future cardiovascular and other co-morbidities. •SDB in children with neuromuscular disease are associated with systemic inflammation.•Pro-inflammatory IL-6 are higher in patients with increased desaturations.•Adhesion molecules ICAM-1 and VCAM-1 are higher in patients with high overnight CO2.•IL-6, VCAM-1, ICAM-1 can mediate cardiovascular and viral co-morbidities in long-surviving neuromuscular patients.
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2020.03.032