Impact of Early Initiation of Direct-Acting Antiviral Therapy in Thoracic Organ Transplantation From Hepatitis C Virus Positive Donors

• Published in: Seminars in thoracic and cardiovascular surgery 2021-01, Vol.33 (2), p.407-415
• Main Authors: Smith, Deane E., Chen, Stacey, Fargnoli, Anthony, Lewis, Tyler, Galloway, Aubrey C., Kon, Zachary N., Moazami, Nader
• Format: Article
• Language: English
• Subjects: direct-acting antiviral therapy; hepatitis C virus infection; thoracic organ transplantation
• ISSN: 1043-0679; 1532-9488
• DOI: 10.1053/j.semtcvs.2020.06.045

Thoracic organs from hepatitis C virus (HCV) positive donors are not commonly used for transplantation. The development of direct-acting antivirals (DAA) for HCV treatment has led to renewed interest in using HCV-positive organs. We evaluated HCV transmission rates, viremia clearance, and short-term outcomes in HCV-negative patients who received HCV-positive thoracic organs at our institution. From January 1, 2018 to May 31, 2019, 38 patients underwent HCV-positive thoracic organ transplantation (16 lungs and 22 hearts). Heart recipients were started on glecaprevir/pibrentasvir, a pangenotypic DAA, when they developed HCV viremia. Lung recipients were empirically started on glecaprevir/pibrentasvir within the first 3 post-transplant days. The primary outcome was cure of HCV defined as sustained virologic response at 12 weeks (SVR12). All heart recipients developed HCV viremia with median initial viral load of 64,565 IU/mL (interquartile range: 1660–473,151). The median time from DAA initiation to viremia clearance was 19 days (confidence interval: 15–27 days). Eleven out of 16 (68.8%) lung recipients developed HCV viremia with median initial viral load of 26 IU/mL (interquartile range: 15–143). The median time from DAA initiation to viremia clearance was 10 days (confidence interval: 6–17 days). Five out of 16 (31.3%) lung recipients never became viremic. All patients demonstrated SVR12. Thoracic organ transplantation from HCV viremic donors is safe with excellent short-term survival. Early initiation of HCV treatment results in rapid viremia clearance and SVR12. Long-term outcomes and optimal timing of DAA initiation remains to be determined. [Display omitted]