Sex difference in clinical presentation of patients with infectious mononucleosis caused by Epstein-Barr virus

There are few studies on sex difference in patients with infectious mononucleosis caused by Epstein-Barr virus (EBV-IM). We performed a retrospective study to evaluate the sex difference in clinical presentation of patients with EBV-IM. We performed a single-center retrospective study evaluating >...

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Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2020-11, Vol.26 (11), p.1181-1185
Main Authors: Sasaki, Yosuke, Ishii, Takamasa, Maeda, Tadashi, Mori, Takeo, Shigeta, Tomoyuki, Kashiwagi, Katsuhito, Komatsu, Fumiya, Yamada, Atsushi, Kijima, Sho, Takemoto, Ikutaka, Miyazaki, Taito, Urita, Yoshihisa
Format: Article
Language:English
Subjects:
Adult
Epstein-Barr Virus Infections - diagnosis
Epstein-Barr Virus Infections - epidemiology
Female
Headache
Hepatitis
Herpesvirus 4, Human
Humans
Infectious Mononucleosis - epidemiology
Male
Periorbital edema
Retrospective Studies
Sex Characteristics
Sex difference
Transaminase
Viral infection
Young Adult
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Summary:There are few studies on sex difference in patients with infectious mononucleosis caused by Epstein-Barr virus (EBV-IM). We performed a retrospective study to evaluate the sex difference in clinical presentation of patients with EBV-IM. We performed a single-center retrospective study evaluating >14-year-old patients with serologically confirmed EBV-IM during 2006–2017. We compared the patients’ age, symptoms, physical findings, and laboratory data between male and female patients. To adjust for confounding factors, we performed a logistic regression analysis based on the results of univariate comparisons. Of the 122 eligible patients (56 male and 66 female, ratio: 1:1.2), the median ages were 26 years old (interquartile range [IR], 22–31.5 years old]) and 22 years old (IR, 20–25 years old) for males and females, respectively (p 30 years old, headache, and leukocyte >11,000/mm3 had high odds ratios. Our single-center retrospective study suggests that older age of onset, headache, and leukocytosis are more likely to be characteristics of male patients with EBV-IM. Our study also underscores the importance of periorbital edema as a clue for early diagnosis of EBV-IM, especially in female patients.
ISSN:1341-321X
1437-7780
DOI:10.1016/j.jiac.2020.06.009