Sex difference in clinical presentation of patients with infectious mononucleosis caused by Epstein-Barr virus

There are few studies on sex difference in patients with infectious mononucleosis caused by Epstein-Barr virus (EBV-IM). We performed a retrospective study to evaluate the sex difference in clinical presentation of patients with EBV-IM. We performed a single-center retrospective study evaluating >...

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Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2020-11, Vol.26 (11), p.1181-1185
Main Authors: Sasaki, Yosuke, Ishii, Takamasa, Maeda, Tadashi, Mori, Takeo, Shigeta, Tomoyuki, Kashiwagi, Katsuhito, Komatsu, Fumiya, Yamada, Atsushi, Kijima, Sho, Takemoto, Ikutaka, Miyazaki, Taito, Urita, Yoshihisa
Format: Article
Language:English
Subjects:
Adult
Epstein-Barr Virus Infections - diagnosis
Epstein-Barr Virus Infections - epidemiology
Female
Headache
Hepatitis
Herpesvirus 4, Human
Humans
Infectious Mononucleosis - epidemiology
Male
Periorbital edema
Retrospective Studies
Sex Characteristics
Sex difference
Transaminase
Viral infection
Young Adult
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cited_by cdi_FETCH-LOGICAL-c424t-c57566e37858724cad423aa697df61da7c00dfa89bbdf0063b89a8d0b4abad523
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container_title Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
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creator Sasaki, Yosuke
Ishii, Takamasa
Maeda, Tadashi
Mori, Takeo
Shigeta, Tomoyuki
Kashiwagi, Katsuhito
Komatsu, Fumiya
Yamada, Atsushi
Kijima, Sho
Takemoto, Ikutaka
Miyazaki, Taito
Urita, Yoshihisa
description There are few studies on sex difference in patients with infectious mononucleosis caused by Epstein-Barr virus (EBV-IM). We performed a retrospective study to evaluate the sex difference in clinical presentation of patients with EBV-IM. We performed a single-center retrospective study evaluating >14-year-old patients with serologically confirmed EBV-IM during 2006–2017. We compared the patients’ age, symptoms, physical findings, and laboratory data between male and female patients. To adjust for confounding factors, we performed a logistic regression analysis based on the results of univariate comparisons. Of the 122 eligible patients (56 male and 66 female, ratio: 1:1.2), the median ages were 26 years old (interquartile range [IR], 22–31.5 years old]) and 22 years old (IR, 20–25 years old) for males and females, respectively (p 30 years old, headache, and leukocyte >11,000/mm3 had high odds ratios. Our single-center retrospective study suggests that older age of onset, headache, and leukocytosis are more likely to be characteristics of male patients with EBV-IM. Our study also underscores the importance of periorbital edema as a clue for early diagnosis of EBV-IM, especially in female patients.
doi_str_mv 10.1016/j.jiac.2020.06.009
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We performed a retrospective study to evaluate the sex difference in clinical presentation of patients with EBV-IM. We performed a single-center retrospective study evaluating &gt;14-year-old patients with serologically confirmed EBV-IM during 2006–2017. We compared the patients’ age, symptoms, physical findings, and laboratory data between male and female patients. To adjust for confounding factors, we performed a logistic regression analysis based on the results of univariate comparisons. Of the 122 eligible patients (56 male and 66 female, ratio: 1:1.2), the median ages were 26 years old (interquartile range [IR], 22–31.5 years old]) and 22 years old (IR, 20–25 years old) for males and females, respectively (p &lt; 0.001). Headache was significantly more prevalent in males (25.0% vs. 10.6%, p = 0.036). Leukocyte count was also significantly higher in males (11,400/mm3 [IR, 7,600–14,100/mm3] vs. 9,400/mm3 [IR, 6,600–11,600/mm3], p = 0.021). The prevalence of periorbital edema (male: 3.6% vs. female: 18.1%, p = 0.012) and severity of transaminase elevation were significantly higher in females. The regression analysis evaluating clinical characteristics of male patients showed that age &gt;30 years old, headache, and leukocyte &gt;11,000/mm3 had high odds ratios. Our single-center retrospective study suggests that older age of onset, headache, and leukocytosis are more likely to be characteristics of male patients with EBV-IM. 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subjects Adult
Epstein-Barr Virus Infections - diagnosis
Epstein-Barr Virus Infections - epidemiology
Female
Headache
Hepatitis
Herpesvirus 4, Human
Humans
Infectious Mononucleosis - epidemiology
Male
Periorbital edema
Retrospective Studies
Sex Characteristics
Sex difference
Transaminase
Viral infection
Young Adult
title Sex difference in clinical presentation of patients with infectious mononucleosis caused by Epstein-Barr virus
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