Regadenoson-induced T-wave heterogeneity complements coronary stenosis detection by myocardial perfusion imaging in men and women

Abstract Aims  We analysed whether incorporating electrocardiographic interlead T-wave heterogeneity (TWH) with myocardial perfusion imaging (MPI) during pharmacologic stress improves detection of flow-limiting lesions (FLL). Methods and results  Medical records of all 103 patients at our institutio...

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Published in:European heart journal cardiovascular imaging 2021-11, Vol.22 (11), p.1341-1349
Main Authors: Araujo Silva, Bruna, Hauser, Thomas H, Nearing, Bruce D, Bortolotto, Alexandre L, Marum, Alexandre A, Tessarolo Silva, Fernanda, Medeiros, Sofia A, Pedreira, Giovanna C, Gervino, Ernest V, Verrier, Richard L
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Language:English
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Summary:Abstract Aims  We analysed whether incorporating electrocardiographic interlead T-wave heterogeneity (TWH) with myocardial perfusion imaging (MPI) during pharmacologic stress improves detection of flow-limiting lesions (FLL). Methods and results  Medical records of all 103 patients at our institution who underwent stress testing with regadenoson (0.4 mg IV bolus) within 3 months of coronary angiography from September 2017 to March 2019 were studied. Cases (N = 59) had angiographically significant FLL (≥50% of left main or ≥70% of other epicardial coronary arteries ≥2 mm in diameter); controls (N = 44) were normal or had non-FLL. TWH, i.e., interlead splay of T waves, was assessed from precordial leads V4–6 by second central moment analysis. Maximum TWHV4–6 levels during regadenoson stress were 68% higher in cases than in controls (P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jeaa128