Prematurity at less than 24 weeks of gestation is a risk for prolonged hyperglycemia in extremely low-birth weight infants

• Published in: Endocrine 2020-10, Vol.70 (1), p.71-77
• Main Authors: Yamauchi, Takeru, Imamura, Masatoshi, Takasawa, Kei, Nakajima, Keisuke, Nakagawa, Ryuichi, Gau, Maki, Sugie, Manabu, Taki, Atsuko, Kawai, Masahiko, Kashimada, Kenichi, Morio, Tomohiro
• Format: Article
• Language: English
• Subjects: Birth weight; Blood glucose; Diabetes; Endocrinology; Gestational age; Glucocorticoids; Glucose metabolism; Humanities and Social Sciences; Hyperglycemia; Infants; Insulin; Internal Medicine; Low birth weight; Medicine; Medicine & Public Health; multidisciplinary; Multivariate analysis; Original Article; Remission; Risk factors; Science
• ISSN: 1355-008X; 1559-0100
• DOI: 10.1007/s12020-020-02393-3

Hyperglycemia in extremely low-birth weight infants (ELBWIs) is frequently observed during the acute perinatal phase, (i.e., first 1–2 weeks postnatal period); however it can occasionally persists for >2 weeks, extending to the post-acute phase. Since such prolonged hyperglycemia (PH) is not typical for ELBWIs, the aim of the present study was to further understand the clinical details of PH. Twenty-five hyperglycemic ELBWIs born before 28 weeks of gestation from 2015 to 2018 were included in the study. Based on the duration of hyperglycemia, we separated the subjects into two groups: non-prolonged hyperglycemia (NPH) who achieved remission within ≤2 weeks [ n  = 18, median 3.0 (range, 2.0–4.0) days], and PH, whose hyperglycemia persisted for >2 weeks [ n  = 7, median 50.0 (range, 33.5–66.0) days]. Compared to the NPH group, glucose metabolism of the PH group was more deteriorate. The peak blood glucose level was significantly higher in the PH group [PH: median 472 mg/dL, NPH: median 275 mg/dL, p