Effects of alkaline agents on respiratory characteristics in rabbit models of respiratory failure

•Alkaline agents may reduce strong inspiratory efforts in respiratory failure.•Trometamol inhibited ventilation more than NaHCO3 in a hypercapnia model.•Trometamol reduced transpulmonary pressure in a lung injury model.•Trometamol may reduce the strong inspiratory effort induced by respiratory failu...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2020-09, Vol.280, p.103485-103485, Article 103485
Main Authors: Yamashita, Tomonori, Uchiyama, Akinori, Koyama, Yukiko, Yoshida, Takeshi, Tanaka, Aiko, Fujino, Yuji
Format: Article
Language:English
Subjects:
Hypercapnia
Lung injury
NaHCO3 inspiratory effort
Transpulmonary pressure
Trometamol
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Summary:•Alkaline agents may reduce strong inspiratory efforts in respiratory failure.•Trometamol inhibited ventilation more than NaHCO3 in a hypercapnia model.•Trometamol reduced transpulmonary pressure in a lung injury model.•Trometamol may reduce the strong inspiratory effort induced by respiratory failure. This study aimed to investigate the effects of alkaline agents on reducing strong inspiratory effort. Rabbits with hypercapnia or lung injury, induced via repeated lung lavage following injurious ventilation, were treated with Saline, NaHCO3, or Trometamol. In the hypercapnia, minute ventilation and tidal volume were unchanged during NaHCO3 administration; however, one hour after the end of NaHCO3 these parameters decreased (82.1+/−7.8 %, 90.8+/−6.0 % of the baseline, respectively, p 
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2020.103485