Current status of breast cancer screening in high-risk women in Japan

Overseas, the importance for breast MRI screening for high-risk groups has been shown. However, the evidence among Japanese population was lacking. Therefore, we collaborated with the “Study on clinical and genetic characterization of hereditary breast and ovarian cancer and improvement in prognosis...

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Bibliographic Details
Published in:Breast cancer (Tokyo, Japan) Japan), 2021-11, Vol.28 (6), p.1181-1187
Main Authors: Tozaki, Mitsuhiro, Nakamura, Seigo
Format: Article
Language:English
Subjects:
Adult
BRCA1 Protein
BRCA2 Protein
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer
Cancer Research
Diagnosis
Female
Gene mutations
Genetic aspects
Humans
Japan
Magnetic Resonance Imaging - standards
Mammography
Mammography - methods
Mass Screening
Medical colleges
Medicine
Medicine & Public Health
Middle Aged
Oncology
Oncology, Experimental
Ovarian cancer
Risk Factors
Special Feature
Surgery
Surgical Oncology
Women
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Summary:Overseas, the importance for breast MRI screening for high-risk groups has been shown. However, the evidence among Japanese population was lacking. Therefore, we collaborated with the “Study on clinical and genetic characterization of hereditary breast and ovarian cancer and improvement in prognosis using genetic information in Japan” group, as part of the Comprehensive Research Project on the Promotion of Cancer Control, Health and Labour Sciences Research, and have been conducting the study entitled, “Study of the usefulness of MRI surveillance of BRCA1/2 mutation carriers” since 2014. In addition, we found that in the Japanese population also, the pathological and imaging characteristics differ between BRCA1 and BRCA2 mutation carriers, like in non-Japanese populations by the several reports. In high-risk females, risk categories such as BRCA1 or BRCA2 mutation carriers are very important. Furthermore, in the future, the optimal surveillance modalities and examination intervals would also vary according to the age, thinness of the breast (constitution), breast density (individual differences on mammography), etc.; this would be “personalized surveillance”, and quality-assured MRI examination is of the essence. This review will present clinical trial data of prospective MRI surveillance in Japan, and summarize the current status of breast cancer screening in high-risk Japanese women.
ISSN:1340-6868
1880-4233
DOI:10.1007/s12282-020-01103-1