Towards multi‐modal data fusion for super‐resolution and denoising of 4D‐Flow MRI

4D‐Flow magnetic resonance imaging (MRI) has enabled in vivo time‐resolved measurement of three‐dimensional blood flow velocities in the human vascular system. However, its clinical use has been hampered by two main issues, namely, low spatio‐temporal resolution and acquisition noise. While patient‐...

Full description

Saved in:
Bibliographic Details
Published in:International journal for numerical methods in biomedical engineering 2020-09, Vol.36 (9), p.e3381-n/a
Main Authors: Perez‐Raya, Isaac, Fathi, Mojtaba F., Baghaie, Ahmadreza, Sacho, Raphael H., Koch, Kevin M., D'Souza, Roshan M.
Format: Article
Language:English
Subjects:
4D‐Flow MRI
Aneurysm
Blood flow
Boundary conditions
CFD
Computational fluid dynamics
Computer applications
Computer simulation
Data integration
Decomposition
DMD
Flow velocity
Fluid dynamics
hemodynamics
Hydrodynamics
Magnetic resonance imaging
Mapping
Modal data
Model accuracy
Noise
Noise reduction
Parameter estimation
POD
Proper Orthogonal Decomposition
Temporal resolution
Vascular system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:4D‐Flow magnetic resonance imaging (MRI) has enabled in vivo time‐resolved measurement of three‐dimensional blood flow velocities in the human vascular system. However, its clinical use has been hampered by two main issues, namely, low spatio‐temporal resolution and acquisition noise. While patient‐specific computational fluid dynamics (CFD) simulations can address the resolution and noise issues, its fidelity is impacted by accuracy of estimation of boundary conditions, model parameters, vascular geometry, and flow model assumptions. In this paper a scheme to address limitations of both modalities through data‐fusion is presented. The solutions of the patient‐specific CFD simulation are characterized using proper orthogonal decomposition (POD). Next, a process of projecting the 4D‐Flow MRI data onto the POD basis and projection coefficient mapping using generalized dynamic mode decomposition (DMD) enables simultaneous super‐resolution and denoising of 4D‐Flow MRI. The method has been tested using numerical phantoms derived from patient‐specific aneurysmal geometries and applied to in vivo 4D‐Flow MRI data.
ISSN:2040-7939
2040-7947
DOI:10.1002/cnm.3381